Kosuke Watari相关文献与解析，生知库 | 链接生命科学的每一步

Peng Zhang ，Junlai Liu ，Allen Lee ，Irene Tsaur ，Masafumi Ohira ，Vivian Duong ，Nicholas Vo ，Kosuke Watari ，Hua Su ，Ju Youn Kim ，Li Gu ，Mandy Zhu ，Shabnam Shalapour ，Mojgan Hosseini ，Gautam Bandyopadhyay ，Suling Zeng ，Cristina Llorente ，Haoqi Nina Zhao ，Santosh Lamichhane ，Siddharth Mohan ，Pieter C Dorrestein ，Jerrold M Olefsky ，Bernd Schnabl ，Pejman Soroosh ，Michael Karin

STAT3

IL-2

细胞生物学

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

果糖-1,6-二磷酸酶是一种非酶促安全阀，它能抑制AKT的激活，从而防止胰岛素过度反应。

期刊:Cell Metabolism

影响因子:27.7

doi:10.1016/j.cmet.2023.03.021

Li Gu ,Yahui Zhu ,Kosuke Watari ,Maiya Lee ,Junlai Liu ,Sofia Perez ,Melinda Thai ,Joshua E Mayfield ,Bichen Zhang ,Karina Cunha E Rocha ,Fuming Li ,Laura C Kim ,Alexander C Jones ,Igor H Wierzbicki ,Xiao Liu ,Alexandra C Newton ,Tatiana Kisseleva ,Jun Hee Lee ,Wei Ying ,David J Gonzalez ,Alan R Saltiel ,M Celeste Simon ,Michael Karin

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

氧化DNA片段通过mPTP和VDAC依赖性通道离开线粒体，激活NLRP3炎症小体和干扰素信号通路。

期刊:Immunity

影响因子:25.5

doi:10.1016/j.immuni.2022.06.007

Hongxu Xian ，Kosuke Watari ，Elsa Sanchez-Lopez ，Joseph Offenberger ，Janset Onyuru ，Harini Sampath ，Wei Ying ，Hal M Hoffman ，Gerald S Shadel ，Michael Karin

AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer

AXL/CDCP1/SRC 轴导致肺癌对奥希替尼产生获得性耐药

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-022-12995-8

Yuichi Murakami, Daiki Kusakabe, Kosuke Watari, Akihiko Kawahara, Koichi Azuma, Jun Akiba, Masahiko Taniguchi, Michihiko Kuwano, Mayumi Ono

Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma

NDRG1 和 GSK3β 之间的双向调节控制肿瘤生长，并成为胶质母细胞瘤中分化诱导因子 1 的靶点

期刊:Cancer Research

影响因子:12.5

doi:10.1158/0008-5472.CAN-19-0438

Hiroshi Ito, Kosuke Watari, Tomohiro Shibata, Tomofumi Miyamoto, Yuichi Murakami, Yukiko Nakahara, Hiroto Izumi, Hiroaki Wakimoto, Michihiko Kuwano, Tatsuya Abe, Mayumi Ono

NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells

NDRG1通过PLCγ1/ERK信号通路激活小鼠血管内皮细胞中VEGF-A诱导的血管生成。

期刊:Communications Biology

影响因子:5.2

doi:10.1038/s42003-020-0829-0

Kosuke Watari ，Tomohiro Shibata ，Hideaki Fujita ，Ai Shinoda ，Yuichi Murakami ，Hideyuki Abe ，Akihiko Kawahara ，Hiroshi Ito ，Jun Akiba ，Shigeo Yoshida ，Michihiko Kuwano ，Mayumi Ono

The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes

5-氮杂胞苷增强胞苷脱氨酶基因表达可预测骨髓增生异常综合征的治疗效果

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.26784

Yuichi Murakami, Yoshizo Kimura, Akihiko Kawahara, Shohei Mitsuyasu, Hidetoshi Miyake, Kaoru Tohyama, Yoshio Endo, Nao Yoshida, Yutaka Imamura, Kosuke Watari, Mayumi Ono, Takashi Okamura, Michihiko Kuwano

信号转导

发表日期：2019

文献求助收藏

The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells

SRC 家族激酶和粘着斑激酶的激活以及扩增、突变的 EGFR 基因的丢失导致人类肺癌细胞对阿法替尼、厄洛替尼和奥希替尼产生耐药性

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.19982

Yuichi Murakami, Kahori Sonoda, Hideyuki Abe, Kosuke Watari, Daiki Kusakabe, Koichi Azuma, Akihiko Kawahara, Jun Akiba, Chitose Oneyama, Jonathan A Pachter, Kazuko Sakai, Kazuto Nishio, Michihiko Kuwano, Mayumi Ono

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

巨噬细胞谱系细胞分化受损会减弱 Ndrg1 缺陷小鼠的骨重塑和炎症血管生成

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/srep19470

Kosuke Watari, Tomohiro Shibata, Hiroshi Nabeshima, Ai Shinoda, Yuichi Fukunaga, Akihiko Kawahara, Kazuyuki Karasuyama, Jun-Ichi Fukushi, Yukihide Iwamoto, Michihiko Kuwano, Mayumi Ono

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma

mTOR Ser2481 的磷酸化是限制雷帕霉素类似物治疗肝细胞癌疗效的关键靶点

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.10161

Kosuke Watari, Ayumi Nishitani, Tomohiro Shibata, Masaki Noda, Akihiko Kawahara, Jun Akiba, Yuichi Murakami, Hirohisa Yano, Michihiko Kuwano, Mayumi Ono

IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

IL-22 通过肠细胞 STAT3 恢复饮食紊乱引起的肠道稳态来缓解 MASLD

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

果糖-1,6-二磷酸酶是一种非酶促安全阀，它能抑制AKT的激活，从而防止胰岛素过度反应。

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

氧化DNA片段通过mPTP和VDAC依赖性通道离开线粒体，激活NLRP3炎症小体和干扰素信号通路。

AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer

AXL/CDCP1/SRC 轴导致肺癌对奥希替尼产生获得性耐药

Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma

NDRG1 和 GSK3β 之间的双向调节控制肿瘤生长，并成为胶质母细胞瘤中分化诱导因子 1 的靶点

NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells

NDRG1通过PLCγ1/ERK信号通路激活小鼠血管内皮细胞中VEGF-A诱导的血管生成。

The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes

5-氮杂胞苷增强胞苷脱氨酶基因表达可预测骨髓增生异常综合征的治疗效果

The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells

SRC 家族激酶和粘着斑激酶的激活以及扩增、突变的 EGFR 基因的丢失导致人类肺癌细胞对阿法替尼、厄洛替尼和奥希替尼产生耐药性

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

巨噬细胞谱系细胞分化受损会减弱 Ndrg1 缺陷小鼠的骨重塑和炎症血管生成

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma

mTOR Ser2481 的磷酸化是限制雷帕霉素类似物治疗肝细胞癌疗效的关键靶点