Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
配体与远端位点的结合,从热力学角度纠正了人类囊性纤维化跨膜传导调节因子中的 F508del 突变
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA117.000819
Wang Chi, Aleksandrov Andrei A, Yang Zhengrong, Forouhar Farhad, Proctor Elizabeth A, Kota Pradeep, An Jianli, Kaplan Anna, Khazanov Netaly, Boël Grégory, Stockwell Brent R, Senderowitz Hanoch, Dokholyan Nikolay V, Riordan John R, Brouillette Christie G, Hunt John F