日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation.

效应子-宿主相互作用组图谱将健康肠道微生物群中的 III 型分泌系统与免疫调节联系起来。

Young Veronika, Dohai Bushra, Halder Hridi, Fernandez-Macgregor Jaime, van Heusden Niels S, Hitch Thomas C A, Weller Benjamin, Hyden Patrick, Saha Deeya, Pieren Daan K J, Rittchen Sonja, Lambourne Luke, Maseko Sibusiso B, Lin Chung-Wen, Tun Ye Min, Bibus Jonas, Pletschacher Luisa, Boujeant Mégane, Choteau Sébastien A, Bergogne Lou, Perrin Jérémie, Ober Franziska, Schwehn Patrick, Rothballer Simin T, Altmann Melina, Altmann Stefan, Strobel Alexandra, Rothballer Michael, Tofaute Marie, Kotlarz Daniel, Heinig Matthias, Clavel Thomas, Calderwood Michael A, Vidal Marc, Twizere Jean-Claude, Vincentelli Renaud, Krappmann Daniel, Boes Marianne, Falter Claudia, Rattei Thomas, Brun Christine, Zanzoni Andreas, Falter-Braun Pascal

A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.

一系列患者来源的肠道类器官系揭示了与儿童炎症性肠病遗传驱动因素相关的上皮表型。

Shojaei Jeshvaghani Zahra, Argmann Carmen, de Vries Maaike H, van Es Johan H, Collen Lauren V, Kotlarz Daniel, Sveen Mia, Comella Phillip H, Snapper Scott B, Klein Christoph, Schadt Eric E, Clevers Hans, Mokry Michal, Kuijk Ewart, Nieuwenhuis Edward

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

SATB1是人Treg细胞和Tconv细胞中JAK-STAT信号通路和细胞因子的可靶向调节因子。

Kolb, Saskia; Diekmann, Leonie; Lochert, Elizabeth D; Warmuth, Linda; Ritter, Julia; Weber, Michael; Hoffmann, Markus; List, Markus; Kotlarz, Daniel; Serr, Isabelle; Daniel, Carolin; Busch, Dirk H; Schmidl, Christian; Schumann, Kathrin

A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease.

一系列源自患者的肠道类器官系揭示了与儿童炎症性肠病遗传驱动因素相关的上皮表型

Jeshvaghani Zahra Shojaei, Argmann Carmen, Mokry Michal, van Es Johan H, de Vries Maaike H, Collen Lauren V, Kotlarz Daniel, Sveen Mia, Comella Phillip, Snapper Scott B, Klein Christoph, Schadt Eric, Clevers Hans, Kuijk Ewart, Nieuwenhuis Edward

Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

优化的人类肠道类器官模型揭示了潘氏细胞形成对白细胞介素-22的依赖性

He, Gui-Wei; Lin, Lin; DeMartino, Jeff; Zheng, Xuan; Staliarova, Nadzeya; Dayton, Talya; Begthel, Harry; van de Wetering, Willine J; Bodewes, Eduard; van Zon, Jeroen; Tans, Sander; Lopez-Iglesias, Carmen; Peters, Peter J; Wu, Wei; Kotlarz, Daniel; Klein, Christoph; Margaritis, Thanasis; Holstege, Frank; Clevers, Hans

Dysregulated inflammasome activity in intestinal inflammation - Insights from patients with very early onset IBD

肠道炎症中炎症小体活性失调——来自极早期发病炎症性肠病患者的启示

Illig, David; Kotlarz, Daniel

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.

STXBP3 的变异与极早期发病的炎症性肠病、双侧感觉神经性听力损失和免疫失调有关

Ouahed Jodie, Kelsen Judith R, Spessott Waldo A, Kooshesh Kameron, Sanmillan Maria L, Dawany Noor, Sullivan Kathleen E, Hamilton Kathryn E, Slowik Voytek, Nejentsev Sergey, Neves João Farela, Flores Helena, Chung Wendy K, Wilson Ashley, Anyane-Yeboa Kwame, Wou Karen, Jain Preti, Field Michael, Tollefson Sophia, Dent Maiah H, Li Dalin, Naito Takeo, McGovern Dermot P B, Kwong Andrew C, Taliaferro Faith, Ordovas-Montanes Jose, Horwitz Bruce H, Kotlarz Daniel, Klein Christoph, Evans Jonathan, Dorsey Jill, Warner Neil, Elkadri Abdul, Muise Aleixo M, Goldsmith Jeffrey, Thompson Benjamin, Engelhardt Karin R, Cant Andrew J, Hambleton Sophie, Barclay Andrew, Toth-Petroczy Agnes, Vuzman Dana, Carmichael Nikkola, Bodea Corneliu, Cassa Christopher A, Devoto Marcella, Maas Richard L, Behrens Edward M, Giraudo Claudio G, Snapper Scott B

Predictive Prenatal Diagnosis for Infantile-onset Inflammatory Bowel Disease Because of Interleukin-10 Signalling Defects

预测性产前诊断婴儿期发病的白细胞介素-10信号缺陷引起的炎症性肠病

Ye, Ziqing; Hu, Wenhui; Wu, Bingbing; Zhang, Yueping; Lei, Caixia; Williams, Isabelle; Shouval, Dror S; Kanegane, Hirokazu; Kim, Kyung Mo; de Ridder, Lissy; Shah, Neil; Ling, Galina; Yerushalmi, Baruch; Kotlarz, Daniel; Snapper, Scott; Horn, Ruth; Klein, Christoph; Muise, Aleixo M; Huang, Ying; Uhlig, Holm H

Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition

临床基因组学在单基因型炎症性肠病诊断中的应用:欧洲儿科胃肠病学、肝病学和营养学会儿科炎症性肠病波尔图小组的立场文件

Uhlig, Holm H; Charbit-Henrion, Fabienne; Kotlarz, Daniel; Shouval, Dror S; Schwerd, Tobias; Strisciuglio, Caterina; de Ridder, Lissy; van Limbergen, Johan; Macchi, Marina; Snapper, Scott B; Ruemmele, Frank M; Wilson, David C; Travis, Simon P L; Griffiths, Anne M; Turner, Dan; Klein, Christoph; Muise, Aleixo M; Russell, Richard K

Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center

单中心1000名儿童全外显子组测序鉴定的与单基因变异相关的炎症性肠病患病率和临床特征

Crowley, Eileen; Warner, Neil; Pan, Jie; Khalouei, Sam; Elkadri, Abdul; Fiedler, Karoline; Foong, Justin; Turinsky, Andrei L; Bronte-Tinkew, Dana; Zhang, Shiqi; Hu, Jamie; Tian, David; Li, Dalin; Horowitz, Julie; Siddiqui, Iram; Upton, Julia; Roifman, Chaim M; Church, Peter C; Wall, Donna A; Ramani, Arun K; Kotlarz, Daniel; Klein, Christoph; Uhlig, Holm; Snapper, Scott B; Gonzaga-Jauregui, Claudia; Paterson, Andrew D; McGovern, Dermot P B; Brudno, Michael; Walters, Thomas D; Griffiths, Anne M; Muise, Aleixo M