日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors

晚期胃肠道肿瘤中基于循环肿瘤DNA分析的靶向治疗

Nakamura, Yoshiaki; Ozaki, Hiroshi; Ueno, Makoto; Komatsu, Yoshito; Yuki, Satoshi; Esaki, Taito; Taniguchi, Hiroya; Sunakawa, Yu; Yamaguchi, Kensei; Kato, Ken; Denda, Tadamichi; Nishina, Tomohiro; Takahashi, Naoki; Satoh, Taroh; Yasui, Hisateru; Satake, Hironaga; Oki, Eiji; Kato, Takeshi; Ohta, Takashi; Matsuhashi, Nobuhisa; Goto, Masahiro; Okano, Naohiro; Ohtsubo, Koushiro; Yamazaki, Kentaro; Yamashita, Riu; Iida, Naoko; Yuasa, Mihoko; Bando, Hideaki; Yoshino, Takayuki

Pembrolizumab efficacy in a tumor mutation burden-high glioblastoma patient: A case study and implications for precision oncology

帕博利珠单抗治疗肿瘤突变负荷高胶质母细胞瘤患者的疗效:病例研究及其对精准肿瘤学的启示

Nishiyama, Akihiro; Sato, Shigeki; Sakaguchi, Hiroyuki; Kotani, Hiroshi; Yamashita, Kaname; Ohtsubo, Koushiro; Sekiya, Tomoko; Watanabe, Atsushi; Tajima, Atsushi; Shimaguchi, Chie; Mizuguchi, Keishi; Ikeda, Hiroko; Kinoshita, Masashi; Nakada, Mitsutoshi; Takeuchi, Shinji

Case Report: Medullary carcinoma of the pancreas with MLH1 promoter hypermethylation, induced deficient mismatch repair, successfully treated with an immune checkpoint inhibitor

病例报告:胰腺髓样癌伴MLH1启动子高甲基化,导致错配修复缺陷,经免疫检查点抑制剂治疗后获得成功。

Ohtsubo, Koushiro; Sato, Shigeki; Sakaguchi, Hiroyuki; Kotani, Hiroshi; Nishiyama, Akihiro; Yamashita, Kaname; Yano, Seiji; Toshima, Fumihito; Inoue, Dai; Gabata, Toshifumi; Ikeda, Hiroko; Watanabe, Atsushi; Notohara, Kenji; Fujisawa, Takao; Nakamura, Yoshiaki; Yoshino, Takayuki; Miyake, Kunio; Miwa, Kazuhiro; Takeuchi, Shinji

Microbiome Landscape and Association with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors: A SCRUM-Japan MONSTAR-SCREEN Study

微生物组格局及其与晚期实体瘤免疫检查点抑制剂疗效的关联:一项来自日本 SCRUM-MONSTAR-SCREEN 的研究

Kentaro Sawada #,Riu Yamashita #,Shunsuke A Sakai #,Satoshi Horasawa,Ayumu Yoshikawa,Takao Fujisawa,Shigenori Kadowaki,Ken Kato,Makoto Ueno,Eiji Oki,Yoshito Komatsu,Tatsuyuki Chiyoda,Yosuke Horita,Hisateru Yasui,Tadamichi Denda,Hironaga Satake,Taito Esaki,Taroh Satoh,Naoki Takahashi,Kentaro Yamazaki,Nobuhisa Matsuhashi,Tomohiro Nishina,Hiroyuki Takeda,Koushiro Ohtsubo,Takashi Ohta,Akihito Tsuji,Masahiro Goto,Takeshi Kato,Hideaki Bando,Katsuya Tsuchihara,Yoshiaki Nakamura,Takayuki Yoshino

Effectiveness of Additional Immunosuppressive Drugs for Corticosteroid-refractory Immune Checkpoint Inhibitor-induced Myocarditis: Two Case Reports

额外免疫抑制剂治疗皮质类固醇难治性免疫检查点抑制剂诱发性心肌炎的疗效:两例病例报告

Sakaguchi, Hiroyuki; Nanjo, Shigeki; Sato, Shigeki; Kotani, Hiroshi; Nishiyama, Akihiro; Yamashita, Kaname; Ohtsubo, Koushiro; Suzuki, Chiaki; Shimojima, Masaya; Yano, Seiji; Takeuchi, Shinji

Resistance mechanism to pembrolizumab in DEK-AFF2 fusion-associated sinonasal squamous cell carcinoma

DEK-AFF2融合相关鼻窦鳞状细胞癌对帕博利珠单抗的耐药机制

Boku, Shogen; Fujisawa, Takao; Kadowaki, Shigenori; Satake, Hironaga; Yasui, Hisateru; Ohtsubo, Koushiro; Shimizu, Yasushi; Otsuka, Tomoyuki; Kuze, Bunya; Yamashita, Riu; Shibuki, Taro; Nakamura, Yoshiaki; Bando, Hideaki; Yoshino, Takayuki; Radovich, Milan; Okano, Susumu

Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers

在表达MYC的KRAS突变型癌症中,通过双重抑制SUMO化和MEK增强全面的抗肿瘤免疫反应

Kotani, Hiroshi; Yamano, Tomoyoshi; Boucher, Justin C; Sato, Shigeki; Sakaguchi, Hiroyuki; Fukuda, Koji; Nishiyama, Akihiro; Yamashita, Kaname; Ohtsubo, Koushiro; Takeuchi, Shinji; Nishiuchi, Takumi; Oshima, Hiroko; Oshima, Masanobu; Davila, Marco L; Yano, Seiji

Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage

SUMO 化和 MEK 的双重抑制可通过积累 DNA 损伤来治愈 MYC 表达的 KRAS 突变癌症

Hiroshi Kotani, Hiroko Oshima, Justin C Boucher, Tomoyoshi Yamano, Hiroyuki Sakaguchi, Shigeki Sato, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Takumi Nishiuchi, Masanobu Oshima, Marco L Davila, Seiji Yano1

Clinical utility of BRCA and ATM mutation status in circulating tumour DNA for treatment selection in advanced pancreatic cancer

BRCA和ATM基因突变状态在循环肿瘤DNA中对晚期胰腺癌治疗选择的临床应用价值

Sudo, Kentaro; Nakamura, Yoshiaki; Ueno, Makoto; Furukawa, Masayuki; Mizuno, Nobumasa; Kawamoto, Yasuyuki; Okano, Naohiro; Umemoto, Kumiko; Asagi, Akinori; Ozaka, Masato; Ohtsubo, Koushiro; Shimizu, Satoshi; Matsuhashi, Nobuhisa; Itoh, Shinji; Matsumoto, Toshihiko; Satoh, Taroh; Okuyama, Hiroyuki; Goto, Masahiro; Hasegawa, Hiroko; Yamamoto, Yoshiyuki; Odegaard, Justin I; Bando, Hideaki; Yoshino, Takayuki; Ikeda, Masafumi; Morizane, Chigusa

Challenges in the treatment of BRAF K601E-mutated lung carcinoma: a case report of rapid response and resistance to dabrafenib and trametinib

BRAF K601E突变型肺癌治疗的挑战:达拉非尼和曲美替尼快速反应和耐药病例报告

Nishiyama, Akihiro; Sato, Shigeki; Sakaguchi, Hiroyuki; Kotani, Hiroshi; Yamashita, Kaname; Ohtsubo, Koushiro; Nanjo, Shigeki; Yano, Seiji; Mizuguchi, Keishi; Ikeda, Hiroko; Takeuchi, Shinji