Kozani相关文献与解析，生知库 | 链接生命科学的每一步

Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs)

通过将转基因位点特异性整合到基因组安全港（GSH）中，预防CAR-T细胞疗法中的继发性原发性恶性肿瘤（SPM）

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-025-07183-x

Safarzadeh Kozani, Pooria; Safarzadeh Kozani, Pouya

Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies

嵌合抗原受体（CAR）-T细胞疗法的抗原依赖性耐药机制

期刊:Cancer Cell International

影响因子:6

doi:10.1186/s12935-025-03697-y

Nasiri, Fatemeh; Safarzadeh Kozani, Pouya; Salem, Faeze; Mahboubi Kancha, Maral; Dashti Shokoohi, Setareh; Safarzadeh Kozani, Pooria

Novel sACE2-Anti-CD16VHH Fusion Protein Surreptitiously Inhibits SARS-CoV-2 Variant Spike Proteins and Macrophage Cytokines, and Activates Natural Killer Cell Cytotoxicity.

新型 sACE2-抗 CD16VHH 融合蛋白可悄然抑制 SARS-CoV-2 变异刺突蛋白和巨噬细胞细胞因子，并激活自然杀伤细胞的细胞毒性

期刊:Vaccines

影响因子:3.4

doi:10.3390/vaccines13020199

Sheikhi Abdolkarim, Baghaie Leili, Rahbarizadeh Fatemeh, Safarzadeh Kozani Pooria, Moradian Cobra, Davidi Mohammadreza, Baharifar Narges, Kaboli Golnaz, Sheikhi Mehdi, Li Yunfan, Meghdadi Mohammadamin, Yaish Abdulrahman M, Yu Aiden H, Harless William W, Szewczuk Myron R

Humanization of the antigen-recognition domain does not impinge on the antigen-binding, cytokine secretion, and antitumor reactivity of humanized nanobody-based CD19-redirected CAR-T cells

抗原识别结构域的人源化不会影响基于人源化纳米抗体的 CD19 重定向 CAR-T 细胞的抗原结合、细胞因子分泌和抗肿瘤反应性

期刊:Journal of Translational Medicine

影响因子:6.1

doi:10.1186/s12967-024-05461-8

Pooria Safarzadeh Kozani #, Pouya Safarzadeh Kozani #, Fatemeh Rahbarizadeh

Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

嵌合抗原受体（CAR）T细胞疗法中的位点特异性转基因整合

期刊:Biomarker Research

影响因子:11.5

doi:10.1186/s40364-023-00509-1

Dabiri, Hamed; Safarzadeh Kozani, Pooria; Habibi Anbouhi, Mahdi; Mirzaee Godarzee, Mohadeseh; Haddadi, Mohammad Hossein; Basiri, Mohsen; Ziaei, Vahab; Sadeghizadeh, Majid; Hajizadeh Saffar, Ensiyeh

Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display

通过噬菌体展示从骆驼免疫文库中分离的新型 CD19 特异性 VHH 的表征

期刊:Journal of Translational Medicine

影响因子:6.1

doi:10.1186/s12967-023-04524-6

Mahmoud Ganji, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh

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发表日期：2023

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CAR-T cell immunotherapy for ovarian cancer: hushing the silent killer

CAR-T细胞免疫疗法治疗卵巢癌：终结沉默杀手

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2023.1302307

Nasiri, Fatemeh; Farrokhi, Khadijeh; Safarzadeh Kozani, Pouya; Mahboubi Kancha, Maral; Dashti Shokoohi, Setareh; Safarzadeh Kozani, Pooria

T-cells engineered with a novel VHH-based chimeric antigen receptor against CD19 exhibit comparable tumoricidal efficacy to their FMC63-based counterparts

利用新型VHH基嵌合抗原受体改造的抗CD19 T细胞，其肿瘤杀伤效力与基于FMC63的同类细胞相当。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2023.1063838

Fatemeh Nasiri ，Pooria Safarzadeh Kozani ，Fatemeh Rahbarizadeh

CAR-T cell immunotherapy in rhabdomyosarcoma

CAR-T细胞免疫疗法治疗横纹肌肉瘤

A Virtual Clinical Trial to Detect Changes in Tumor Uptake with PET using Lesion Embedding

利用病灶嵌入技术检测PET肿瘤摄取变化的虚拟临床试验

Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs)

通过将转基因位点特异性整合到基因组安全港（GSH）中，预防CAR-T细胞疗法中的继发性原发性恶性肿瘤（SPM）

Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies

嵌合抗原受体（CAR）-T细胞疗法的抗原依赖性耐药机制

Novel sACE2-Anti-CD16VHH Fusion Protein Surreptitiously Inhibits SARS-CoV-2 Variant Spike Proteins and Macrophage Cytokines, and Activates Natural Killer Cell Cytotoxicity.

新型 sACE2-抗 CD16VHH 融合蛋白可悄然抑制 SARS-CoV-2 变异刺突蛋白和巨噬细胞细胞因子，并激活自然杀伤细胞的细胞毒性

Humanization of the antigen-recognition domain does not impinge on the antigen-binding, cytokine secretion, and antitumor reactivity of humanized nanobody-based CD19-redirected CAR-T cells

抗原识别结构域的人源化不会影响基于人源化纳米抗体的 CD19 重定向 CAR-T 细胞的抗原结合、细胞因子分泌和抗肿瘤反应性

Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

嵌合抗原受体（CAR）T细胞疗法中的位点特异性转基因整合

Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display

通过噬菌体展示从骆驼免疫文库中分离的新型 CD19 特异性 VHH 的表征

CAR-T cell immunotherapy for ovarian cancer: hushing the silent killer

CAR-T细胞免疫疗法治疗卵巢癌：终结沉默杀手

T-cells engineered with a novel VHH-based chimeric antigen receptor against CD19 exhibit comparable tumoricidal efficacy to their FMC63-based counterparts

利用新型VHH基嵌合抗原受体改造的抗CD19 T细胞，其肿瘤杀伤效力与基于FMC63的同类细胞相当。