日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair

首个真细菌Mre11核酸酶的晶体结构揭示了其在DNA修复过程中可能区分底物的新特征。

Das, Debanu; Moiani, Davide; Axelrod, Herbert L; Miller, Mitchell D; McMullan, Daniel; Jin, Kevin K; Abdubek, Polat; Astakhova, Tamara; Burra, Prasad; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; Deller, Marc C; Duan, Lian; Ernst, Dustin; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Anna; Grzechnik, Slawomir K; Han, Gye Won; Jaroszewski, Lukasz; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Krishna, S Sri; Kumar, Abhinav; Marciano, David; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; Sefcovic, Natasha; Tien, Henry J; Trame, Christine B; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Tainer, John A; Wilson, Ian A

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

Pfam家族首个代表成员PF09410(DUF2006)的结构揭示了钙调蛋白超家族的结构特征,提示其在脂质代谢中发挥作用。

Chiu, Hsiu Ju; Bakolitsa, Constantina; Skerra, Arne; Lomize, Andrei; Carlton, Dennis; Miller, Mitchell D; Krishna, S Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Clayton, Thomas; Deller, Marc C; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Slawomir K; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation

Pfam家族首个代表PF04016(DUF364)的结构揭示了烯醇化酶和Rossmann样折叠,它们共同形成独特的活性位点,可能在重金属螯合中发挥作用。

Miller, Mitchell D; Aravind, L; Bakolitsa, Constantina; Rife, Christopher L; Carlton, Dennis; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chiu, Hsiu Ju; Clayton, Thomas; Deller, Marc C; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Krishna, S Sri; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Reyes, Ron; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation

Pfam家族首个代表蛋白PF09836的结构揭示了其双结构域组织,并提示其可能参与转录调控。

Das, Debanu; Grishin, Nick V; Kumar, Abhinav; Carlton, Dennis; Bakolitsa, Constantina; Miller, Mitchell D; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Burra, Prasad; Chen, Connie; Chiu, Hsiu Ju; Chiu, Michelle; Clayton, Thomas; Deller, Marc C; Duan, Lian; Ellrott, Kyle; Ernst, Dustin; Farr, Carol L; Feuerhelm, Julie; Grzechnik, Anna; Grzechnik, Slawomir K; Grant, Joanna C; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Johnson, Hope A; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Krishna, S Sri; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L; Sefcovic, Natasha; Tien, Henry J; Trame, Christine B; van den Bedem, Henry; Weekes, Dana; Wooten, Tiffany; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism

Pfam家族PF06684(DUF1185)的首个代表菌株的结构揭示了一种新型的芽孢杆菌分支酸变位酶折叠变体,并提示其在氨基酸代谢中发挥作用。

Bakolitsa, Constantina; Kumar, Abhinav; Jin, Kevin K; McMullan, Daniel; Krishna, S Sri; Miller, Mitchell D; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L; Burra, Prasad; Carlton, Dennis; Chen, Connie; Chiu, Hsiu Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C; Duan, Lian; Elias, Ylva; Ellrott, Kyle; Ernst, Dustin; Farr, Carol L; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Anna; Grzechnik, Slawomir K; Han, Gye Won; Jaroszewski, Lukasz; Johnson, Hope A; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Marciano, David; Morse, Andrew T; Murphy, Kevin D; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L; Sefcovic, Natasha; Tien, Henry J; Trame, Christine B; Trout, Christina V; van den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc Andre; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator

来自詹氏菌属(Jannaschia sp.)的 Jann_2411 (DUF1470) 的 1.45 Å 分辨率结构揭示了一种新的折叠结构(ABATE 结构域),并提示其可能作为转录调控因子发挥作用。

Bakolitsa, Constantina; Bateman, Alex; Jin, Kevin K; McMullan, Daniel; Krishna, S Sri; Miller, Mitchell D; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L; Burra, Prasad; Carlton, Dennis; Chiu, Hsiu Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C; Duan, Lian; Elias, Ylva; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Anna; Grzechnik, Slawomir K; Han, Gye Won; Jaroszewski, Lukasz; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; Morse, Andrew T; Murphy, Kevin D; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; Sefcovic, Natasha; Tien, Henry; Trame, Christine B; Trout, Christina V; van den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott; Wilson, Ian A

Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism

LP2179是Pfam家族PF08866的首个代表,其结构揭示了一种新的折叠方式,可能在氨基酸代谢中发挥作用。

Bakolitsa, Constantina; Kumar, Abhinav; Carlton, Dennis; Miller, Mitchell D; Krishna, S Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chiu, Hsiu Ju; Clayton, Thomas; Deller, Marc C; Duan, Lian; Elsliger, Marc André; Feuerhelm, Julie; Grzechnik, Slawomir K; Grant, Joanna C; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; Tien, Henry J; Trout, Christina V; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

Pfam家族首个代表PF06475的结构揭示了一种新的折叠方式,可能参与糖脂代谢。

Bakolitsa, Constantina; Kumar, Abhinav; McMullan, Daniel; Krishna, S Sri; Miller, Mitchell D; Carlton, Dennis; Najmanovich, Rafael; Abdubek, Polat; Astakhova, Tamara; Chiu, Hsiu Ju; Clayton, Thomas; Deller, Marc C; Duan, Lian; Elias, Ylva; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Slawomir K; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Marciano, David; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; Trout, Christina V; van den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction

Pfam家族首个代表成员PF06938(DUF1285)的结构揭示了一种具有重复结构基序的新折叠,并可能参与信号转导。

Han, Gye Won; Bakolitsa, Constantina; Miller, Mitchell D; Kumar, Abhinav; Carlton, Dennis; Najmanovich, Rafael J; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chen, Connie; Chiu, Hsiu Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C; Duan, Lian; Ernst, Dustin; Feuerhelm, Julie; Grant, Joanna C; Grzechnik, Anna; Jaroszewski, Lukasz; Jin, Kevin K; Johnson, Hope A; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Krishna, S Sri; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Reyes, Ron; Rife, Christopher L; Sefcovic, Natasha; Tien, Henry J; Trame, Christine B; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Elsliger, Marc André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A