日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome

出生后甲基胞嘧啶向羟甲基胞嘧啶的转化重塑了人类神经元表观基因组。

Xu, Heng; Chien, Jo-Fan; Kozlenkov, Alexey; Vadukapuram, Ramu; Li, Junhao; Wei, Yu; Dwork, Andrew J; Liu, Chunyu; Dracheva, Stella; Mukamel, Eran A

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease

大规模单核多组学研究发现帕金森病的新型罕见非编码驱动基因

Menon, Shreya; Turner, Adam W; Chang, Serena H; Johnson, Alia W; Chang, Heather H; Shah, Aayushi J; Zeng, Youjie; Strohlein, Colleen E; Kampman, Lucas; Colston, Courtney; Kozlenkov, Alexey; Dracheva, Stella; Avenali, Micol; Palermo, Giovanni; Ceravolo, Roberto; Valente, Enza Maria; Gabbert, Carolin; Trinh, Joanne; Serrano, Geidy E; Beach, Thomas G; Shulman, Joshua M; Blauwendraat, Cornelis; Montine, Thomas J; Fang, Zih-Hua; Belloy, Michael E; Corces, M Ryan

Epidural Thin Film Implants of Polymerized Curcumin Downregulate Inflammatory Markers and Improve Functional Recovery After Spinal Cord Injury in Mice.

硬膜外植入聚合姜黄素薄膜可下调炎症标志物,并改善小鼠脊髓损伤后的功能恢复。

Toro Carlos A, Johnson Nicholas P, Suhail Zaraa, Chen Ruiwen, Leman John T, Waskiewicz Nikita, Khalique Shahrukh, Oroshi Granit, Jayaraman Gomathi, Kozlenkov Alexey, Iyengar Ravi, Gilbert Ryan, Cardozo Christopher P, Palermo Edmund F, Siddiq Mustafa M

Repeat expansions in C9orf72 rewire the 3D chromatin landscape in ALS.

C9orf72 中的重复扩增会重塑 ALS 中的 3D 染色质结构。

Avila Tatiana Ulloa, Wang Jingying, Adams Lydia, Hu Ellen, Beltran Alvaro A, Kozlenkov Alexey, Urhekar Shreyan, Gonzalez Ariana B Marquez, Lee Hun-Goo, Calabrese J Mauro, Dracheva Stella, Beltran Adriana S, Mah Won, Won Hyejung

Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience

阿尔茨海默病进展和认知恢复中的单细胞多区域表观基因组重编程

Liu, Zunpeng; Zhang, Shanshan; James, Benjamin T; Galani, Kyriaki; Mangan, Riley J; Fass, Stuart Benjamin; Liang, Chuqian; Wagle, Manoj M; Boix, Carles A; Tanigawa, Yosuke; Yun, Sukwon; Sung, Yena; Xiong, Xushen; Sun, Na; Hou, Lei; Wohlwend, Martin; Qiu, Mufan; Han, Xikun; Xiong, Lei; Preka, Efthalia; Huang, Lei; Li, William F; Ho, Li-Lun; Grayson, Amy; Mantero, Julio; Kozlenkov, Alexey; Mathys, Hansruedi; Chen, Tianlong; Dracheva, Stella; Bennett, David A; Tsai, Li-Huei; Kellis, Manolis

Multiomic single-cell profiling identifies critical regulators of postnatal brain

多组学单细胞分析鉴定出出生后大脑的关键调控因子

Clarence, Tereza; Bendl, Jaroslav; Cao, Xuan; Wang, Xinyi; Zheng, Shiwei; Hoffman, Gabriel E; Kozlenkov, Alexey; Hong, Aram; Iskhakova, Marina; Jaiswal, Manoj K; Murphy, Sarah; Yu, Alexander; Haroutunian, Vahram; Dracheva, Stella; Akbarian, Schahram; Fullard, John F; Yuan, Guo-Cheng; Lee, Donghoon; Roussos, Panos

Author Correction: Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation

作者更正:携带 C9orf72 突变的 ALS 和 FTD 患者的单细胞转录组和表观基因组改变存在差异

Li, Junhao; Jaiswal, Manoj K; Chien, Jo-Fan; Kozlenkov, Alexey; Jung, Jinyoung; Zhou, Ping; Gardashli, Mahammad; Pregent, Luc J; Engelberg-Cook, Erica; Dickson, Dennis W; Belzil, Veronique V; Mukamel, Eran A; Dracheva, Stella

Novel method of isolating nuclei of human oligodendrocyte precursor cells reveals substantial developmental changes in gene expression and H3K27ac histone modification

分离人类少突胶质细胞前体细胞核的新方法揭示了基因表达和 H3K27ac 组蛋白修饰的显著发育变化

Alexey Kozlenkov, Ramu Vadukapuram, Ping Zhou, Peter Fam, Michael Wegner, Stella Dracheva

Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation

C9orf72突变型ALS和FTD患者的单细胞转录组和表观基因组存在差异性改变

Junhao Li #,Manoj K Jaiswal #,Jo-Fan Chien,Alexey Kozlenkov,Jinyoung Jung,Ping Zhou,Mahammad Gardashli,Luc J Pregent,Erica Engelberg-Cook,Dennis W Dickson,Veronique V Belzil,Eran A Mukamel,Stella Dracheva

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

一项针对大量精神分裂症和双相情感障碍患者脑组织的研究表明,染色质结构域的改变与三维基因组组织相关。

Girdhar, Kiran; Hoffman, Gabriel E; Bendl, Jaroslav; Rahman, Samir; Dong, Pengfei; Liao, Will; Hauberg, Mads E; Sloofman, Laura; Brown, Leanne; Devillers, Olivia; Kassim, Bibi S; Wiseman, Jennifer R; Park, Royce; Zharovsky, Elizabeth; Jacobov, Rivky; Flatow, Elie; Kozlenkov, Alexey; Gilgenast, Thomas; Johnson, Jessica S; Couto, Lizette; Peters, Mette A; Phillips-Cremins, Jennifer E; Hahn, Chang-Gyu; Gur, Raquel E; Tamminga, Carol A; Lewis, David A; Haroutunian, Vahram; Dracheva, Stella; Lipska, Barbara K; Marenco, Stefano; Kundakovic, Marija; Fullard, John F; Jiang, Yan; Roussos, Panos; Akbarian, Schahram