日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma

基于ASO的PKM剪接转换疗法可提高抗CTLA-4抗体在胰腺导管腺癌中的疗效

Han, Lijie; Gan, Lina; Schäfer, Balázs; Voss, Dillon M; Danielsen, Mathias; Kostov, Ondrej; Liu, Jia; Wang, Ting; Caruthers, Marvin H; Chen, Hao; Krainer, Adrian R

Targeting EZH2 Oncogenic Splicing: Decoding the Regulatory Network and Antisense Correction

靶向 EZH2 致癌剪接:解码调控网络和反义校正

Islam, Md Rafikul; Nagar, Preeti; McNaughton, Naomi; Heeamoni, Shabiha Afroj; Hasan, Md Mahbub; Kandel, Shila; Tsakiroglou, Panagiotis; Dalton, William Brian; Abdel-Wahab, Omar; Krainer, Adrian R; Rahman, Mohammad Alinoor

Exon-Skipping Antisense Oligonucleotides for H3.3K27M-Altered Diffuse Midline Glioma Therapy

用于治疗 H3.3K27M 突变型弥漫性中线胶质瘤的外显子跳跃反义寡核苷酸

Yang, Lucia; Zhang, Qian; Wilkinson, John E; Krainer, Adrian R

Voltage-gated sodium channels in excitable cells as drug targets

可兴奋细胞中的电压门控钠通道作为药物靶点

Alsaloum, Matthew; Dib-Hajj, Sulayman D; Page, Dana A; Ruben, Peter C; Krainer, Adrian R; Waxman, Stephen G

Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy

羊膜腔内反义寡核苷酸治疗可改善脊髓性肌萎缩症临床前模型的表型

Borges, Beltran; Brown, Stephen M; Chen, Wan-Jin; Clarke, Maria T; Herzeg, Akos; Park, Jae Hong; Ross, Joshua; Kong, Lingling; Denton, Madeline; Smith, Amy K; Lum, Tony; Zada, Fareha Moulana; Cordero, Marco; Gupta, Nalin; Cook, Sarah E; Murray, Heather; Matson, John; Klein, Stephanie; Bennett, C Frank; Krainer, Adrian R; MacKenzie, Tippi C; Sumner, Charlotte J

New insights into biomarkers and risk stratification to predict hepatocellular cancer

生物标志物和风险分层在预测肝细胞癌方面的新见解

Li, Katrina; Mathew, Brandon; Saldanha, Ethan; Ghosh, Puja; Krainer, Adrian R; Dasarathy, Srinivasan; Huang, Hai; Xiang, Xiyan; Mishra, Lopa

PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

PKM剪接转换反义寡核苷酸诱导肝细胞癌中双特异性磷酸酶上调和ERK1/2去磷酸化

Voss, Dillon M; Kral, Alexander J; Sim, GeunYoung; Utama, Raditya; Lin, Kuan-Ting; Cizmeciyan, Chris; Schafer, Balazs; Cunniff, Patrick J; Vakoc, Christopher R; Caruthers, Marvin H; Mishra, Lopa; Krainer, Adrian R

Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer.

微生物代谢产物氨会破坏 TGF-β 信号传导,从而促进结肠癌的发生

Bhowmick Krishanu, Yang Xiaochun, Mohammad Taj, Xiang Xiyan, Molmenti Christine L, Mishra Bibhuti, Dasarathy Srinivasan, Krainer Adrian R, Hassan Md Imtaiyaz, Crandall Keith A, Mishra Lopa

MYC-Driven Activation of USP39 Enhances SRSF1 Stability and Promotes PDAC Progression

MYC驱动的USP39激活增强SRSF1稳定性并促进PDAC进展

Ma, Benteng; Kral, Alexander J; Zhang, Xin; Singh, Neelu; Deschenes, Astrid; Cifani, Paolo; Park, Youngkyu; Tuveson, David A; Krainer, Adrian R; Wan, Ledong

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

靶向毒性限制了 CDK11 抑制剂对 1p36 缺失癌症的疗效

Julian Linda, Crozier Lisa, Lukow Devon, Mishra Sanat, Swamy Aditi, Hagenson Ryan A, Sennhenn Peter, Sausville Erin L, Mendelson Brianna, Chuaqui Claudio, Qiao Lu, Vasudevan Anand, Lin Kuan-Ting, Bhatia Sonam, Bertomeu Thierry, Chatr-Aryamontri Andrew, Zhang Li, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Nottoli Timothy, Bai Suxia, Lakshmipathi Jayalakshmi, Muthusamy Viswanathan, Van Vranken Jonathan G, Gygi Steven P, Thompson Sarah L, Smith Joan C, Anderson Kendall, Shah Sanjana, Bindra Ranjit S, Akerman Martin, Spector David L, Krainer Adrian R, Sheltzer Jason M