日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva

Zilurgisertib 的发现和表征:一种强效且选择性的激活素受体样激酶-2 (ALK2) 抑制剂,用于治疗进行性骨化性纤维发育不良症

Ullrich, Thomas; Guth, Sabine; Arista, Luca; Weiler, Sven; Stiefl, Nikolaus; Teixeira-Fouchard, Sylvie; Dekker, Carien; Hinniger, Alexandra; Head, Victoria; Kneissel, Michaela; Kramer, Ina

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

抑制WNT分泌可减少由Lrp5基因中Sost功能丧失或功能获得突变引起的高骨量。

Diegel, Cassandra R; Kramer, Ina; Moes, Charles; Foxa, Gabrielle E; McDonald, Mitchell J; Madaj, Zachary B; Guth, Sabine; Liu, Jun; Harris, Jennifer L; Kneissel, Michaela; Williams, Bart O

Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice

雄性Sost缺陷小鼠皮质骨对中等程度机械负荷的适应性

Yang, Haisheng; Büttner, Alexander; Albiol, Laia; Julien, Catherine; Thiele, Tobias; Figge, Christine; Kramer, Ina; Kneissel, Michaela; Duda, Georg N; Checa, Sara; Willie, Bettina M

Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis

受发育启发,对成人人类间充质干细胞进行编程,使其向稳定的软骨形成方向发展。

Occhetta, Paola; Pigeot, Sebastien; Rasponi, Marco; Dasen, Boris; Mehrkens, Arne; Ullrich, Thomas; Kramer, Ina; Guth-Gundel, Sabine; Barbero, Andrea; Martin, Ivan

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis

骨骼细胞衍生的分子硬骨蛋白驱动骨髓脂肪生成

Fairfield, Heather; Falank, Carolyne; Harris, Elizabeth; Demambro, Victoria; McDonald, Michelle; Pettitt, Jessica A; Mohanty, Sindhu T; Croucher, Peter; Kramer, Ina; Kneissel, Michaela; Rosen, Clifford J; Reagan, Michaela R

Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice

在小鼠体内应变匹配负荷实验中,Sost 缺乏会导致胫骨中段机械应变降低。

Albiol, Laia; Cilla, Myriam; Pflanz, David; Kramer, Ina; Kneissel, Michaela; Duda, Georg N; Willie, Bettina M; Checa, Sara

Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease

患有慢性肾病的野生型小鼠和硬骨蛋白敲除小鼠在肾性骨营养不良特征方面仅有细微差异。

Cejka, Daniel; Parada-Rodriguez, Diego; Pichler, Stefanie; Marculescu, Rodrig; Kramer, Ina; Kneissel, Michaela; Gross, Thomas; Reisinger, Andreas; Pahr, Dieter; Monier-Faugere, Marie-Claude; Haas, Martin; Malluche, Hartmut H

Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible

软骨发育不全中的梅克尔氏软骨和髁突软骨异常会导致下颌骨发育和生长缺陷。

Biosse Duplan, Martin; Komla-Ebri, Davide; Heuzé, Yann; Estibals, Valentin; Gaudas, Emilie; Kaci, Nabil; Benoist-Lasselin, Catherine; Zerah, Michel; Kramer, Ina; Kneissel, Michaela; Porta, Diana Grauss; Di Rocco, Federico; Legeai-Mallet, Laurence

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy.

在进行性肾性骨营养不良大鼠模型中应用抗硬骨蛋白抗体进行治疗

Moe Sharon M, Chen Neal X, Newman Christopher L, Organ Jason M, Kneissel Michaela, Kramer Ina, Gattone Vincent H 2nd, Allen Matthew R

Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels

通过基因敲除或药物阻断破坏Lrp4功能可增加骨量和血清硬骨蛋白水平。

Chang, Ming-Kang; Kramer, Ina; Huber, Thomas; Kinzel, Bernd; Guth-Gundel, Sabine; Leupin, Olivier; Kneissel, Michaela