日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors.

肿瘤特异性 HORMAD1 表达扰乱有丝分裂停滞,并导致对有丝分裂激酶抑制剂的敏感性。

Walker Callum, Kollarovic Gabriel, Weekes Daniel, Trendell Jennifer, Hoffmann Ricarda M, Martin Alexia, Ferro Riccardo, Navarro-Llinas Blanca, Hitchen Luke, Pardo Calvo Mercedes, Balan Nicolae, Kemp Harriet, Carroll Alexandra, Davidson Kathryn, Nath Sarmi, D'Uonno Nadja, Lu Ruifang, Starling Chris, Otten Marieke, Iakobachvili Nino, Marcozzi Chiara, Rahman Ilhan, Quist Jelmar, Yu Lu, Krastev Dragomir B, Amodeo Valeria, Roxanis Ioannis, Grigoriadis Anita, Bayliss Richard, Choudhary Jyoti, Haider Syed, Pines Jonathon, Pettitt Stephen J, Lord Christopher J, Tutt Andrew N J

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.

PARP 抑制剂 talazoparib 与呼肠孤病毒协同作用,可在小鼠模型中诱导癌细胞死亡和肿瘤控制

Kyula-Currie Joan, Roulstone Victoria, Wright James, Butera Francesca, Legrand Arnaud, Elliott Richard, McLaughlin Martin, Bozhanova Galabina, Krastev Dragomir, Pettitt Stephen, Tenev Tencho, Dillon Magnus, Foo Shane, Patin Emmanuel C, Jennings Victoria, Chan Wah Hak Charleen, Appleton Elizabeth, Wongariyapak Amarin, Pedersen Malin, Rullan Antonio, Choudhary Jyoti, Bakal Chris, Meier Pascal, Lord Christopher J, Melcher Alan, Harrington Kevin J

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

捕捉到的 PARP1 活性状态快照揭示了 PARP1 变构的机制

Rouleau-Turcotte Élise, Krastev Dragomir B, Pettitt Stephen J, Lord Christopher J, Pascal John M

Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.

USP28 和 SPINT2 表达的丧失促进了癌细胞在全基因组加倍后的存活

Bernhard Sara Vanessa, Seget-Trzensiok Katarzyna, Kuffer Christian, Krastev Dragomir B, Stautmeister Lisa-Marie, Theis Mirko, Keuper Kristina, Boekenkamp Jan-Eric, Kschischo Maik, Buchholz Frank, Storchova Zuzana

Opinion: PARP inhibitors in cancer-what do we still need to know?

观点:PARP抑制剂在癌症治疗中的作用——我们还需要了解什么?

Wicks, Andrew J; Krastev, Dragomir B; Pettitt, Stephen J; Tutt, Andrew N J; Lord, Christopher J

Structural basis for allosteric PARP-1 retention on DNA breaks

DNA断裂处PARP-1变构保留的结构基础

Zandarashvili, Levani; Langelier, Marie-France; Velagapudi, Uday Kiran; Hancock, Mark A; Steffen, Jamin D; Billur, Ramya; Hannan, Zain M; Wicks, Andrew J; Krastev, Dragomir B; Pettitt, Stephen J; Lord, Christopher J; Talele, Tanaji T; Pascal, John M; Black, Ben E

A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia

一项全基因组DNA修复RNAi筛选鉴定出SPG48是与遗传性痉挛性截瘫相关的新基因

Słabicki, Mikołaj; Theis, Mirko; Krastev, Dragomir B; Samsonov, Sergey; Mundwiller, Emeline; Junqueira, Magno; Paszkowski-Rogacz, Maciej; Teyra, Joan; Heninger, Anne-Kristin; Poser, Ina; Prieur, Fabienne; Truchetto, Jérémy; Confavreux, Christian; Marelli, Cécilia; Durr, Alexandra; Camdessanche, Jean Philippe; Brice, Alexis; Shevchenko, Andrej; Pisabarro, M Teresa; Stevanin, Giovanni; Buchholz, Frank