日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing

小环状干扰 RNA(sciRNA)作为基因沉默的有效治疗平台

Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe, Krishna Aluri, John Szeto, Pawan Kumar, Sarah LeBlanc, Tim Racie, Christopher R Brown, Adam Castoreno, Dale C Guenther, Vasant Jadhav, Martin A Maier, Janez Plavec, Martin Egli, Muthiah Manoharan, Ivan Zlatev

Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates

GalNAc-siRNA 结合物中 2'-脱氧-2'-氟核苷酸的安全性评估

Maja M Janas, Ivan Zlatev, Ju Liu, Yongfeng Jiang, Scott A Barros, Jessica E Sutherland, Wendell P Davis, Jingxuan Liu, Christopher R Brown, Xiumin Liu, Mark K Schlegel, Lauren Blair, Xuemei Zhang, Biplab Das, Chris Tran, Krishna Aluri, Jing Li, Saket Agarwal, Ramesh Indrakanti, Klaus Charisse, Jaya

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates

增强代谢稳定性对 GalNAc-siRNA 结合物的药代动力学和药效学的影响

Jayaprakash K Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R Brown, Swati Gupta, Jennifer L S Willoughby, Julie A Boshar, Vasant Jadhav, Klaus Charisse, Tracy Zimmermann, Kev