Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain.

STAT1 二聚体上磷酸酪氨酸的去磷酸化需要单体进行广泛的空间重新定向，而这种重新定向是由 N 端结构域促进的