日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Water Networks as Hydrophobic Recognition Motifs in Proteins

水网络作为蛋白质中的疏水识别基序

Piticchio, Serena G; Martínez-Cartró, Miriam; Scaffidi, Salvatore; Rodríguez-Arévalo, Sergio; Bagán, Andrea; Sánchez-Arfelis, Ainoa; Picaud, Sarah; Krojer, Tobias; Filippakopoulos, Panagis; von Delft, Frank; Escolano, Carmen; Galdeano, Carles; Barril, Xavier

Crystallographic fragment screening supports tool compound discovery and reveals conformational flexibility in human deoxyhypusine synthase

晶体学片段筛选有助于发现工具化合物,并揭示人脱氧次黄嘌呤合成酶的构象灵活性

Wilk, Piotr; Wątor-Wilk, Elżbieta; Muszak, Damian; Kochanowski, Paweł; Krojer, Tobias; Grudnik, Przemysław

Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography

结合位点活性化合物纯化(B-SPA)结合多步阵列合成和高通量晶体学,可实现片段先导化合物的高效大规模筛选。

Grosjean, Harold; Aimon, Anthony; Hassell-Hart, Storm; Thompson, Warren; Koekemoer, Lizbé; Bennett, James; Bradley, Anthony; Anderson, Cameron; Wild, Conor; Bradshaw, William J; FitzGerald, Edward A; Krojer, Tobias; Fedorov, Oleg; Biggin, Philip C; Spencer, John; von Delft, Frank

Status and perspective of protein crystallography at the first multi-bend achromat based synchrotron MAX IV

首个基于多弯消色差透镜的同步辐射光源 MAX IV 的蛋白质晶体学现状与展望

Gonzalez, Ana; Krojer, Tobias; Nan, Jie; Bjelčić, Monika; Aggarwal, Swati; Gorgisyan, Ishkan; Milas, Mirko; Eguiraun, Mikel; Casadei, Cecilia; Chenchiliyan, Manoop; Jurgilaitis, Andrius; Kroon, David; Ahn, Byungnam; Ekström, John Carl; Aurelius, Oskar; Lang, Dean; Ursby, Thomas; Thunnissen, Marjolein M G M

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

SARS-CoV-2 NSP15 核糖核酸内切酶的变构调节和晶体学片段筛选

Godoy, Andre Schutzer; Nakamura, Aline Minalli; Douangamath, Alice; Song, Yun; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Fernandes, Rafaela Sachetto; Pereira, Humberto D Muniz; Oliveira, Ketllyn Irene Zagato; Fearon, Daren; Dias, Alexandre; Krojer, Tobias; Fairhead, Michael; Powell, Alisa; Dunnet, Louise; Brandao-Neto, Jose; Skyner, Rachael; Chalk, Rod; Bajusz, Dávid; Bege, Miklós; Borbás, Anikó; Keserű, György Miklós; von Delft, Frank; Oliva, Glaucius

Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data

关于问题和机遇——如何处理以及如何不处理晶体学碎片筛选数据

Weiss, Manfred S; Wollenhaupt, Jan; Correy, Galen J; Fraser, James S; Heine, Andreas; Klebe, Gerhard; Krojer, Tobias; Thunissen, Marjolein; Pearce, Nicholas M

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies

开发用于大型X射线晶体学驱动的蛋白质-配体研究的软件的经验

Pearce, Nicholas M; Skyner, Rachael; Krojer, Tobias

Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening

基于晶体学的片段筛选揭示人类乙醇酸氧化酶抑制剂的新起点

Sabrina R Mackinnon, Gustavo A Bezerra, Tobias Krojer, Tamas Szommer, Frank von Delft, Paul E Brennan, Wyatt W Yue

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

对与 SARS-CoV-2 nsp10 结合的片段的鉴定揭示了 nsp10 和 nsp14/nsp16 之间保守界面上的配体结合位点。

Kozielski, Frank; Sele, Céleste; Talibov, Vladimir O; Lou, Jiaqi; Dong, Danni; Wang, Qian; Shi, Xinyue; Nyblom, Maria; Rogstam, Annika; Krojer, Tobias; Fisher, Zoë; Knecht, Wolfgang

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

片段筛选揭示了合理设计半乳糖激酶 1 抑制剂治疗经典型半乳糖血症的起点。

Mackinnon, Sabrina R; Krojer, Tobias; Foster, William R; Diaz-Saez, Laura; Tang, Manshu; Huber, Kilian V M; von Delft, Frank; Lai, Kent; Brennan, Paul E; Arruda Bezerra, Gustavo; Yue, Wyatt W