日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

发现一种非核苷类抑制剂,可与呼吸道合胞病毒 RNA 依赖性 RNA 聚合酶掌状结构域中的新位点结合

Kalin Jay H, Yin Yanting, Tran Minh T, Piassek Madison, Fung Amy, Grosse Sandrine, Jacoby Edgar, Bhaumik Anusarka, Adhikary Suraj, Miller Robyn, Lemmens Cynthia, Lutter Ferdinand H, Pieters Serge, Cooymans Ludwig, Rombouts Geert, Oehlrich Daniel, Tomaso Sonia, Lozada Kate, Garcia Miguel Osorio, Anson Brandon, De Bruyn Suzanne, Smith-Monroy Constance, Neefs Jean-Marc, Conceição-Neto Nádia, Stoops Bart, van Vlijmen Herman, Patrick Aaron, Yu Xiaodi, Wong Victoria, Krosky Daniel, Abeywickrema Pravien, Mason Stephen, Jin Zhinan, Jonckers Tim H M, Sharma Sujata

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias

强效、选择性menin-KMT2A抑制剂JNJ-75276617(bleximenib)在KMT2A和NPM1改变的白血病中的临床前疗效

Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne; Pande, Vineet; Marien, Ann; Goffin, Dries; Wenge, Daniela V; Yue, Hong; Cutler, Jevon A; Jin, Cyrus; Perner, Florian; Hogeling, Shanna M; Shaffer, Paul L; Jacobs, Frank; Vinken, Petra; Cai, Wei; Keersmaekers, Vikki; Eyassu, Filmon; Bhogal, Balpreet; Verstraeten, Karin; El Ashkar, Sara; Perry, Jennifer A; Jayaguru, Prathiba; Barreyro, Laura; Kuchnio, Anna; Darville, Nicolas; Krosky, Daniel; Urbanietz, Gregor; Verbist, Bie; Edwards, James P; Cowley, Glenn S; Kirkpatrick, Robert; Steele, Ruth; Ferrante, Lucille; Guttke, Christina; Daskalakis, Nikki; Pietsch, E Christine; Wilson, David M; Attar, Ricardo; Elsayed, Yusri; Fischer, Eric S; Schuringa, Jan Jacob; Armstrong, Scott A; Packman, Kathryn; Philippar, Ulrike

Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor

人精胺氧化酶与高选择性变构抑制剂复合物的结构

Diaz, Elsie; Adhikary, Suraj; Tepper, Armand W J W; Riley, Daniel; Ortiz-Meoz, Rodrigo; Krosky, Daniel; Buyck, Christophe; Lamenca, Carolina Martinez; Llaveria, Josep; Fang, Lichao; Kalin, Jay H; Klaren, Vincent N A; Fahmy, Shorouk; Shaffer, Paul L; Kirkpatrick, Robert; Carbajo, Rodrigo J; Thomsen, Maren; Impagliazzo, Antonietta

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

重新定义组蛋白去乙酰化酶抑制剂药效团:高效且无锌辅因子相互作用

Beshore, Douglas C; Adam, Gregory C; Barnard, Richard J O; Burlein, Christine; Gallicchio, Steven N; Holloway, M Katharine; Krosky, Daniel; Lemaire, Wei; Myers, Robert W; Patel, Sangita; Plotkin, Michael A; Powell, David A; Rada, Vanessa; Cox, Christopher D; Coleman, Paul J; Klein, Daniel J; Wolkenberg, Scott E