日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study

新型乌米芬韦衍生物对SARS-CoV-2的抗病毒活性增强:一项国际合作研究的启示

Mottin, Melina; Jurisch, Christopher D; Silva-Mendonça, Sabrina; Seanego, Donald; Ramos, Paulo R P da Silva; Freitas, Caroline S; Mattos, Mayara; Fintelman-Rodrigues, Natalia; Sacramento, Carolina Q; Guivel-Benhassine, Florence; Bruel, Timothée; Krugmann, Liezl; Puhl, Ana C; Urbina, Fabio; Lane, Thomas R; Merten, Eric M; Pearce, Kenneth H; Lepioshkin, Alexander; Poromov, Artem; Monakhova, Natalia; Schwartz, Olivier; Chibale, Kelly; Souza, Thiago M L; Ekins, Sean; Makarov, Vadim; Gessner, Richard K; Andrade, Carolina H

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Deciphering the Anti-LUAD Mechanism of 4′-Demethyl-epipodophyllotoxin (4′-DMEP) via Machine Learning-Driven Target Identification and In Vitro Validation

利用机器学习驱动的靶点识别和体外验证,揭示4′-去甲基表鬼臼毒素(4′-DMEP)的抗肺腺癌机制

Lu, Jingwei; Aggarwal, Reeva; Pompili, Vincent J; Das, Hiranmoy; Chang, Wei; Yu, Jingjing; Di Palma, Roberto; Falco, Luigi; Coccia, Armando; Amitrano, Federica; D'Addio, Giovanni; La Rovere, Maria Teresa; Zhang, Yifang; Bao, Cuiping; Liu, Lingling; Liu, Renjiao; Wang, Xincheng; Guo, Xiaoxuan; Li, Chunjun; Wan, Qiliang; Ding, Yi; Liu, Wenduo; Yang, Kun; Zhang, Yue; Bu, Yifan; Song, Mingrong; Hao, Zhihua; Chen, Jing; Ouro, Alberto; Ben-Dor, Gabriel A; Debasa-Mouce, Manuel; Gulkarov, Shelly; De Leon, Joshua; Castro-Mosquera, Mónica; Sobrino, Tomás; Bougea, Anastasia; Reiss, Allison B; Szőke, Henrik; Vagedes, Jan; Balogh, Anikó; Li, Shengnian; Yin, Yikun; Guan, Jingjun; Yu, Liang; Jin, Shihao; Hu, Haotian; Wang, Xue; Wei, Xuan; Wang, Changjie; Ding, Peisen; Fan, Pengfei; Gao, Sinan; Dou, Xiaojing; Wang, Bing; Ma, Haoran; Yan, Mengwen; Liu, Jun; Zhu, Chen; Soria-Fregozo, Cesar; Ramos de Robles, Silvia Lizette; Flores-Soto, Mario Eduardo; Rosas-Sánchez, Gilberto Uriel; Zhao, Yannan; Deng, Bei; Li, Xiang; Zhang, Sheng; Chen, Yuhang; Peng, Dezhong; Sun, Ning; He, Yi; Liu, Yi-Wei; Chen, Gang-Lin; Chen, Lei; Yang, Hui-Lin; Lu, Jing-Kang; Xiong, Jing; Xiong, Xiao-Yi; He, Cheng-Qi; Barnett, Carlton C; Oliver, Gavin R; Schoenberg, Michael Rutenberg; Smith, Hans P; Smythe, W Roy; Zhang, Lei; Lu, Hao; Zhou, Hao; Bigjahan, Bavrina; Cavallari, Michele; Barisano, Giuseppe; Lange, Martin; Martinasek, Mary; Heckert, Nadine; Duan, Tingting; Zou, Changwei; Yang, Ming; Xu, Jiangxingzi; Wu, Zhaoping; Ullah, Sayyed Aqib; Jabeen, Hafsa; Javed, Areeba; Manan, Abdul; Irshad, Nadeem; Khan, Kashif Maqbool; Khushal, Aneela; Khan, Sara; Farooq, Umar; Bashir, Kashif; Saeed, Aamer; Cole, Paige L; Stead, Connor A; Burniston, Jatin G; Owens, Daniel J; Karnati, Bharath V; Kumar Behera, Pradip; Tripathy, Krishna P; Karanam, Rama Sowmya; Priyadarshini, Aparajita; Das, Swati; Mishra, Subhashree; Treiber, Kyle; Svensson, Robert; Cui, Zhong-lei; Zhang, Wen-hao; Wang, Wei; Han, Shan-shan; Zhu, Sai; Xu, Chuan-yi; Huang, Hua-sheng; Luo, Rong-hai; Pinky, Humayra Afroz; Nishan, MD Nahid Hassan; Alam, Gazi Md Ehsanul; Pathak, Ranjana; Goel, Anjana; Mukherjee, Archana; Patil, Deepali; Zope, Mukesh Kumar; Raj, Rishi; Devi, Seema; Bufacchi, Antonella; Pasciuti, Katia; Tesfaye, Melaku; Baheretibeb, Yonas; Dinku, Tsimona; Mihretu, Awoke; Li, Jie; Wang, Qiao-Yan; Xu, Xin; Cui, Lili; Zhang, Yong; Gu, Jingkai; Behboodi, Hamid-Reza; Asghari-Moghadam, Morteza; Mehri, Mehran; Hamza Ilyas, Muhammad; Daher, Mohammad; Deshpande, Viraj; Lindsay, Adam; Abboud, Joseph A; Kassam, Hafiz F; Yang, Runyu; Feng, Hui; Zhang, Mengyao; Liu, Yi; Luo, Minna; Liu, Ruimin; Wang, Kaiyao; Li, Qijing; Wang, Wenjuan; Chen, Jing; Du, Yue; Xiao, Jiayi; Yang, Bingyu; Niu, Fan; He, Pengcheng; Takahashi, Momo; Tamura, Yuma; Tamiya, Hajime; Terashima, Masato; Takahashi, Harunori; Banba, Nobuyuki; Nakatani, Yuki; Otani, Naoyuki; Ueno, Asuka; Yasu, Takanori; Maejima, Yasuhiro; Liu, Xin; Woo, Sukyung; Elemosho, Abdulaziz; Malekzadeh, Hamid; Kluemper, Jude C; Janis, Jeffrey E; Li, Yanxian; Sang, Jun; Li, Xuemei; Ding, Wenjing; Yang, Chunyan; Yang, Zheng; Zhao, Shiping; Liu, Yanfang; Cardoso, Barbara R; Steele, Euridice Martinez; Brayner, Barbara; Yuan, Xinyi; Bransby, Lisa; Cummins, Hannah; Lim, Yen Ying; Machado, Priscila; Liu, Qiang; Liu, Cui; Qin, Xin; Baba, Ainain; Baba, Obair Yousuf; Ahmad, Abid; Shahid, Misbah; Cho, Hyo-Moon; Le, Minh-Thi-Tuyet; Shin, Ji-Hye; Mai, Van-Hieu; Choi, Seri; An, Jin-Pyo; Lee, Yun-Sil; Oh, Won-Keun; Feng, Fang; Choi, Jihye; Ahn, Dohyun; Truong, Thi My Tien; Yim, Kyung June; Kim, Hyun-Jin; Jung, Man-Young; Lee, Hae-Won; Kim, Dong-Shin; Kang, Inhae; Zhao, Yi; Ai, Wei; Zhao, Jieyu; Yang, Xi; Liu, Wencheng; Ma, Yaru; Mou, Jianrui; Hai, Ao; Ji, Ran; Gan, Yu; Miao, Zhuang; Hu, Shilong; Huang, Zhenbo; Liu, Jin; Liu, Xianggen; Yang, Jun; Ke, Bowen; Khatib, Hasan; Ellsworth, Elijah; Badhwar, Norisha; Zuñiga-Eulogio, Miriam; Quinteros, Michael; Hernández-Moreno, Alberto; Hernández-Moreno, Tadeo; Sharma, Tapan; Olea-Flores, Monserrat; Ordóñez, Mario; Coste-Sanchez, Carla; Padilla-Benavides, Teresita; Navarro-Tito, Napoleón; Lohawittayanan, Duangporn; Khulmanee, Tachin; Thima, Kanthinich; Chabang, Napason; Yenjai, Wanchalerm; Kanjanasirirat, Phongthon; Schlaeppi, Patrick; Tantivess, Varisa; Phumisithikul, Tanadej; Ratcha-in, Detchart; Chotsriluecha, Sanisorn; Chuchaisuwannasri, Dhanita; Phanchana, Matthew; Pinthong, Nattapon; Patrapuvich, Rapatbhorn; Charoensutthivarakul, Sitthivut; Haakonde, Richard; Zyambo, Golden; Changula, Katendi; Mwenechanya, Roy; Muzandu, Kaampwe Mayovu; Mondal, Kalyan; Mandal, Abhijit; Vijay, Anuj; Patel, Ganeshkumar; Gong, Shan; Liu, Yeqian; Chen, Chunming; Feng, Min; Yang, Meiqi; Ren, Weiqiong; Wang, Min; Zhao, Shaojie; Yuan, Hua; Zhao, Min; Hang, Chen; Yuan, Rong; Canal de Velasco, Luis M; González Flores, José Emiliano; Kraus Fischer, Gabriel; Morales Arteaga, Jose Luis; Olivares Casas, María J; Alvarez Nava, Kenia N; Morales Morales, Frida M; Zhao, Tian-Pei; Chen, Jing-Yu; Li, Yue-Hua; Zhang, Chen-Xia; Ma, Yu-Xiang; Qin, Zhao; Wang, Xue-De; Liu, Hua-Min; Cui, Rui-Fu; Wang, Lei; Xu, Yong-Jun; Shi, Hai-Ming; Iizuka, Yusuke; Kosaka, Takuya; Kishi, Takahiro; Mitsuoka, Hiroshi; Yamaguchi, Yuki; Hoshino, Akihiro; Masuda, Hidemichi; Zhou, Xuchang; Wang, Dongxue; Deng, Huili; Guo, Jianmin; Chen, Xier; Lin, Zhangyu; Liu, Baolong; Zhao, Ruobing; Gao, Lu; Yin, Xuan; Zhang, Yun; Chen, Yan; Yang, Yajing; Li, Qingxian; Shen, Qu; Ji, Jianguang; Ni, Guoxin; Abikar, Apoorva; Ranganathan, Prathibha; Mottin, Melina; Jurisch, Christopher D; Silva-Mendonça, Sabrina; Seanego, Donald; Ramos, Paulo R P da Silva; Freitas, Caroline S; Mattos, Mayara; Fintelman-Rodrigues, Natalia; Sacramento, Carolina Q; Guivel-Benhassine, Florence; Bruel, Timothée; Krugmann, Liezl; Puhl, Ana C; Urbina, Fabio; Lane, Thomas R; Merten, Eric M; Pearce, Kenneth H; Lepioshkin, Alexander; Poromov, Artem; Monakhova, Natalia; Schwartz, Olivier; Chibale, Kelly; Souza, Thiago M L; Ekins, Sean; Makarov, Vadim; Gessner, Richard K; Andrade, Carolina H; Liang, Hui; Huang, Qinhong; Xian, Mingming; Chen, Taoliang; Sun, Xinlin; Binorkar, Sandeep V; Sawant, Ranjeet; Ukey, Rashtrapal N; Bhat, Ravindra; Monteblanco, Carlo D; Sy Su, Karl Matthew C; Jose, Geraldine Raphaela B; Yao, Jinghui; Wang, Chenhao; Wang, Zhichao; Xiang, Shi; Sun, Wu; Chen, Hui; Yang, Chao

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum

基于细胞的螺吲哚啉表型先导化合物筛选,最终鉴定出针对人类疟原虫恶性疟原虫具有不同寄生虫学特征的化合物。

Dam, Jean; Boyle, Grant A; Horatscheck, André; Woodland, John G; Le Manach, Claire; Kaur, Gurminder; Taylor, Dale; Krugmann, Liezl; Njoroge, Mathew; Lawrence, Nina; Brunschwig, Christel; Zdorichenko, Victor; Cox, Brian; Wittlin, Sergio; von Geldern, Thomas W; Smith, Dennis; Duffy, James; Basarab, Gregory S; Chibale, Kelly

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Sapanisertib(一种抗癌药物和双重疟原虫磷脂酰肌醇 4-激酶 β 和 cGMP 依赖性蛋白激酶抑制剂,用于治疗疟疾)的药物化学进展

Gachuhi, Samuel; Kamunya, Stephanie; Fienberg, Stephen; Wambua, Lynn; Salomane, Nicolaas; Mayoka, Godfrey; Taylor, Dale; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Birkholtz, Lyn-Marié; Wittlin, Sergio; Krugmann, Liezl; Coulson, Lauren B; Chibale, Kelly

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

Platelets During Myelin Repair in Multiple Sclerosis: Friend or Foe?

血小板在多发性硬化症髓鞘修复中的作用:是敌是友?

Rivera, Francisco J; Philp, Amber R; Reyes, Carolina R; Valenzuela-Krugmann, Carlos; Silva, Maria Elena

MicroRNA Expression in High-Grade B-Cell Lymphoma With 11q Aberration

11q异常高级别B细胞淋巴瘤中microRNA的表达

Di Stefano, Gioia; Fischer, Anja; Chteinberg, Emil; Bens, Susanne; Wagener, Rabea; Abramov, Dmitriy; Adam, Patrick; Bernhart, Stephan H; Borkhardt, Arndt; Burkhardt, Birgit; Del-Val, Coral; Frühwald, Michael C; Guazzo, Raffaella; Hoell, Jessica I; Hummel, Michael; Horn, Heike; Klapper, Wolfram; Krugmann, Jens; Kurz, Katrin S; Lazzi, Stefano; Louissaint, Abner Jr; Mottok, Anja; Oschlies, Ilske; Santi, Raffaella; Schafernak, Kristian; Staiger, Annette M; Zhang, Yanming; Rosenwald, Andreas; Trümper, Lorenz; Leoncini, Lorenzo; Ott, German; Siebert, Reiner

Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination

循环血小板调节髓鞘再生过程中少突胶质细胞祖细胞的分化

Amber R Philp, Carolina R Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao, Carlos Valenzuela-Krugmann, Khalil S Rawji, Ginez A Gonzalez Martinez, Penelope Dimas, Bryan Hinrichsen, César Ulloa-Leal, Amie K Waller, Diana M Bessa de Sousa, Maite A Castro, Ludwig Aigner, Pamela Ehrenfeld, Maria Elena