日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Xylazine's κ opioid agonist activity is not shared with other FDA-approved α(2)-adrenergic agonists

赛拉嗪的κ阿片受体激动剂活性与其他FDA批准的α(2)-肾上腺素能激动剂不同。

Huang, Xi-Ping; Krumm, Brian E; Bedard, Madigan L; McElligott, Zoe A; Roth, Bryan L

Orchestrating NTSR1 signaling from the interface

从接口协调 NTSR1 信号

Huang, Xianglin; Krumm, Brian E; Roth, Bryan L

The structural diversity of psychedelic drug actions revealed

迷幻药作用的结构多样性揭示

Gumpper, Ryan H; Jain, Manish K; Kim, Kuglae; Sun, Renhong; Sun, Ning; Xu, Zhongli; DiBerto, Jeffrey F; Krumm, Brian E; Kapolka, Nicholas J; Kaniskan, H Ümit; Nichols, David E; Jin, Jian; Fay, Jonathan F; Roth, Bryan L

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Michael Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma M; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Intracellular GPCR modulators enable precision pharmacology

细胞内GPCR调节剂可实现精准药理学

Krumm, Brian E; Roth, Bryan L

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors.

从头设计靶向 G 蛋白偶联受体的微型蛋白激动剂和拮抗剂

Muratspahić Edin, Feldman David, Kim David E, Qu Xiangli, Bratovianu Ana-Maria, Rivera-Sánchez Paula, Dimitri Federica, Cao Jason, Cary Brian P, Belousoff Matthew J, Keov Peter, Chen Qingchao, Ren Yue, Fine Justyn, Sappington Isaac, Schlichthaerle Thomas, Zhang Jason Z, Pillai Arvind, Mihaljević Ljubica, Bauer Magnus, Torres Susana Vázquez, Motmaen Amir, Lee Gyu Rie, Tran Long, Wang Xinru, Goreshnik Inna, Vafeados Dionne K, Svendsen Justin E, Hosseinzadeh Parisa, Lindegaard Nicolai, Brandt Matthäus, Waltenspühl Yann, Deibler Kristine, Oostdyk Luke, Cao William, Anantharaman Lakshmi, Stewart Lance, Halloran Lauren, Spangler Jamie B, Sexton Patrick M, Roth Bryan L, Krumm Brian E, Wootten Denise, Tate Christopher G, Norn Christoffer, Baker David

Structure-guided design of a peripherally restricted chemogenetic system.

结构导向的外周限制性化学遗传系统设计

Kang Hye Jin, Krumm Brian E, Tassou Adrien, Geron Matan, DiBerto Jeffrey F, Kapolka Nicholas J, Gumpper Ryan H, Sakamoto Kensuke, Dewran Kocak D, Olsen Reid H J, Huang Xi-Ping, Zhang Shicheng, Huang Karen L, Zaidi Saheem A, Nguyen MyV T, Jo Min Jeong, Katritch Vsevolod, Fay Jonathan F, Scherrer Grégory, Roth Bryan L

High-affinity agonists reveal recognition motifs for the MRGPRD GPCR.

高亲和力激动剂揭示了 MRGPRD GPCR 的识别基序

Wang Chunyu, Liu Yongfeng, Lanier Marion, Yeager Adam, Singh Isha, Gumpper Ryan H, Krumm Brian E, DeLeon Chelsea, Zhang Shicheng, Boehm Marcus, Pittner Richard, Baron Alain, Dvorak Lisa, Bacon Corinne, Shoichet Brian K, Martinborough Esther, Fay Jonathan F, Cao Can, Roth Bryan L

Molecular mechanism of biased signaling at the kappa opioid receptor.

kappa阿片受体偏向性信号传导的分子机制

El Daibani Amal, Paggi Joseph M, Kim Kuglae, Laloudakis Yianni D, Popov Petr, Bernhard Sarah M, Krumm Brian E, Olsen Reid H J, Diberto Jeffrey, Carroll F Ivy, Katritch Vsevolod, Wünsch Bernhard, Dror Ron O, Che Tao