GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
GDF15 通过 SMAD7-HIF-1α-PKM2 级联协调线粒体-免疫串扰,从而减轻脓毒症性肝损伤。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1712741
Kuang Xiandong, Niu Zhili, Liu Wenqiang, Huang Zhaoyang, Li Shuo, Zhang Ye, Wang Li, Cai Xin, Wang Faxi, Zhang Pingan
炎症/感染
败血症
肝损伤
线粒体
SMAD7
毒理研究
免疫/内分泌