日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer

泛素介导的KDM5B稳定化通过抑制双特异性磷酸酶4驱动卵巢癌的化疗耐药性

Jung Yoo,Go Woon Kim,Yu Hyun Jeon,Jaewook Kim,Enzhi Luo,Sang Wu Lee,Soo Yeon Oh,Junjeong Choi,Kuglae Kim,So Hee Kwon

The structural diversity of psychedelic drug actions revealed

迷幻药作用的结构多样性揭示

Gumpper, Ryan H; Jain, Manish K; Kim, Kuglae; Sun, Renhong; Sun, Ning; Xu, Zhongli; DiBerto, Jeffrey F; Krumm, Brian E; Kapolka, Nicholas J; Kaniskan, H Ümit; Nichols, David E; Jin, Jian; Fay, Jonathan F; Roth, Bryan L

Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var

利用首创的线粒体谷氨酰胺转运蛋白SLC1A5_var抑制剂靶向癌症谷氨酰胺依赖性

Yulseung Sung ,Ya Chun Yu ,Mirim Lee ,Seonghun Lim ,Yechan Lee ,Mincheol Kang ,Doru Kwon ,Apeksha Parajulee ,Junjeong Choi ,Do Sik Min ,Kuglae Kim ,Wan Namkung ,Yun-Hee Kim ,Sang Myung Woo ,Nam Doo Kim ,Hee Chan Yoo ,Jung Min Han

AlphaFold2 structures guide prospective ligand discovery

AlphaFold2结构指导潜在配体的发现

Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K; Barros-Álvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Glenn, Isabella S; Tummino, Tia A; Huang, Sijie; Irwin, John J; Tarkhanova, Olga O; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C; Shoichet, Brian K; Roth, Bryan L

AlphaFold2 structures template ligand discovery

AlphaFold2 结构模板配体发现

Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish K Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey DiBerto, Kuglae Kim, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Brya

Molecular mechanism of biased signaling at the kappa opioid receptor.

kappa阿片受体偏向性信号传导的分子机制

El Daibani Amal, Paggi Joseph M, Kim Kuglae, Laloudakis Yianni D, Popov Petr, Bernhard Sarah M, Krumm Brian E, Olsen Reid H J, Diberto Jeffrey, Carroll F Ivy, Katritch Vsevolod, Wünsch Bernhard, Dror Ron O, Che Tao

Structural studies of serotonin receptor family

血清素受体家族的结构研究

Parajulee, Apeksha; Kim, Kuglae

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

针对具有抗抑郁活性的5-HT2A受体激动剂的定制化化合物库对接

Anat Levit Kaplan #,Danielle N Confair #,Kuglae Kim #,Ximena Barros-Álvarez #,Ramona M Rodriguiz,Ying Yang,Oh Sang Kweon,Tao Che,John D McCorvy,David N Kamber,James P Phelan,Luan Carvalho Martins,Vladimir M Pogorelov,Jeffrey F DiBerto,Samuel T Slocum,Xi-Ping Huang,Jain Manish Kumar,Michael J Robertson,Ouliana Panova,Alpay B Seven,Autumn Q Wetsel,William C Wetsel,John J Irwin,Georgios Skiniotis,Brian K Shoichet,Bryan L Roth,Jonathan A Ellman

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

典型迷幻剂LSD激活血清素受体的信号快照

Can Cao,Ximena Barros-Álvarez,Shicheng Zhang,Kuglae Kim,Marc A Dämgen,Ouliana Panova,Carl-Mikael Suomivuori,Jonathan F Fay,Xiaofang Zhong,Brian E Krumm,Ryan H Gumpper,Alpay B Seven,Michael J Robertson,Nevan J Krogan,Ruth Hüttenhain,David E Nichols,Ron O Dror,Georgios Skiniotis,Bryan L Roth

Inactive and active state structures template selective tools for the human 5-HT5A receptor

人类 5-HT5A 受体的非活性和活性状态结构模板选择工具

Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth