日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes

具有不同有氧能力的多基因大鼠模型揭示了肝脑相互作用对阿尔茨海默病样表型的影响

Lysaker, Colton R; Kugler, Benjamin A; Csikos, Vivien; Birky, Cole J; Gilmore, Caleb A; Wenger, Madi; Franczak, Edziu; Davis, Xin; Hauger, Brittany M; Allen, Julie A; Troutwine, Benjamin R; Gonzalez-Duran, Laura; McCoin, Colin S; Chauhan, Munish; Harris, Janna L; Frazier, Alexandria L; Winter, Michelle K; Koch, Lauren G; Britton, Steven L; Thyfault, John P; Wilkins, Heather M

APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model.

在临床前模型中,APOE4 对能量消耗和骨骼肌线粒体通路产生部分饮食依赖性影响

Johnson Chelsea N, Lysaker Colton R, Gast Elaine C, McCoin Colin S, Kemna Riley E, Fuller Kelly N Z, Kugler Benjamin A, Franczak Edziu, Csikos Vivien, Allen Julie, John Casey S, Wolf MaryJane A, Morris Matthew E, Thyfault John P, Wilkins Heather M, Geiger Paige C, Morris Jill K

Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.

卵巢功能丧失会阻止运动诱导的肝脏线粒体自噬通量的激活

Franczak Edziu, Kugler Benjamin A, Salathe Sebastian F, Allen Julie A, Sardiu Mihaela E, McCoin Colin S, Hevener Andrea L, Morris E Matthew, Thyfault John P

Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome

卵巢功能丧失和雌激素疗法会重塑大脑的突触和代谢蛋白质组。

Salathe, Sebastian F; Franczak, Edziu; Busick, Zane; Boakye, Frederick B; Allen, Julie; Lutkewitte, Andrew; Wilkins, Heather; John, Thyfault; Kugler, Benjamin A

Intrinsic aerobic capacity modulates Alzheimer's disease pathological hallmarks, brain mitochondrial function and proteome during aging

内在有氧能力在衰老过程中调节阿尔茨海默病病理特征、脑线粒体功能和蛋白质组。

Kugler, Benjamin A; Lysaker, Colton R; Franczak, Edziu; Hauger, Brittany M; Csikos, Vivien; Stopperan, Julia A; Allen, Julie A; Stanford, John A; Koch, Lauren G; Britton, Steven L; Thyfault, John P; Wilkins, Heather M

High-intensity interval training attenuates impairment in regulatory protein machinery of mitochondrial quality control in skeletal muscle of diet-induced obese mice.

高强度间歇训练可减轻饮食诱导肥胖小鼠骨骼肌线粒体质量控制调节蛋白机制的损伤。

Tincknell James B, Kugler Benjamin A, Spicuzza Haley, Berger Nicolas, Yan Huimin, You Tongjian, Zou Kai

Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes

2型糖尿病重度肥胖女性原代肌管细胞中葡萄糖分配受损

Zou, Kai; Turner, Kristen; Zheng, Donghai; Hinkley, J Matthew; Kugler, Benjamin A; Hornby, Pamela J; Lenhard, James; Jones, Terry E; Pories, Walter J; Dohm, G Lynis; Houmard, Joseph A

Altered mitochondrial network morphology and regulatory proteins in mitochondrial quality control in myotubes from severely obese humans with or without type 2 diabetes.

严重肥胖患者(伴或不伴 2 型糖尿病)肌管中线粒体网络形态和线粒体质量控制调控蛋白的改变。

Gundersen Anders E, Kugler Benjamin A, McDonald Paul M, Veraksa Alexey, Houmard Joseph A, Zou Kai