日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis.

科凯恩综合征小鼠反映了人类肾脏疾病,并且在从头合成 NAD 方面存在缺陷。

Pekhale Komal, Tiwari Vinod, Hussain Mansoor, Bridges Christy C, Croteau Deborah L, Levi Moshe, Rosenberg Avi Z, Santo Briana, Yang Xiaoping, Kulikowicz Tomasz, Wang Xiaoxin X, Lee Jong-Hyuk, Bohr Vilhelm A

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

磷酸化依赖的 WRN-RPA 相互作用促进 DNA 二级结构中停滞分叉的恢复

Alessandro Noto, Pasquale Valenzisi #, Flavia Di Feo #, Federica Fratini, Tomasz Kulikowicz, Joshua A Sommers, Benedetta Perdichizzi, Maurizio Semproni, Valentina Palermo, Marco Crescenzi, Robert M Brosh Jr, Annapaola Franchitto, Pietro Pichierri

SARS-CoV-2 point mutations are over-represented in terminal loops of RNA stem-loop structures that can be resolved by Nsp13 helicase in a unique manner with respect to nucleotide dependence.

SARS-CoV-2 点突变在 RNA 茎环结构的末端环中过度出现,而 Nsp13 解旋酶可以以一种独特的方式解析这些结构,这种解析方式与核苷酸依赖性有关。

Dumm Adaira J, Zheng Andrew Y, Butler Thomas J, Kulikowicz Tomasz, George Joe C, Bombard Pierce T, Sommers Joshua A, Ding Jun, Brosh Robert M Jr

RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining

RECQL4 需要 PARP1 来募集 DNA 损伤,而 PARG 去 PARylation 促进其在末端连接中的相关作用

Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L Croteau, Vilhelm A Bohr

Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis

发现硫氰酸染料是一类新型强效冠状病毒抑制剂,可抑制病毒RNA合成

Zhang, Tianyi; Altouma, Valerie; Sommers, Joshua A; Dumm, Adaira J; Kennedy, Debbie; Xia, Hongjie; Yang, Mo; Fullenkamp, Christopher R; Huang, Shar-Yin N; Xue, Yutong; Su, Shuaikun; Shen, Weiping; Haren, Caitlin E; Kulikowicz, Tomasz; Pommier, Yves; Schneekloth, John S Jr; Garcia-Blanco, Mariano A; Brosh, Robert M Jr; Wang, Weidong

Neuroprotection provided by hypothermia initiated with high transnasal flow with ambient air in a model of pediatric cardiac arrest

在儿童心脏骤停模型中,采用高流量经鼻空气进行低温治疗可提供神经保护作用

Yang, Zeng-Jin; Hopkins, C Danielle; Santos, Polan T; Adams, Shawn; Kulikowicz, Ewa; Lee, Jennifer K; Tandri, Harikrishna; Koehler, Raymond C

Purification and biochemical characterization of the G4 resolvase and DNA helicase FANCJ.

G4 分解酶和 DNA 解旋酶 FANCJ 的纯化和生化特性分析

Kulikowicz Tomasz, Sommers Joshua A, Fuchs Kathleen F, Wu Yuliang, Brosh Robert M Jr

Werner syndrome protein works as a dimer for unwinding and replication fork regression

沃纳综合征蛋白以二聚体的形式发挥作用,解旋并导致复制叉退化

Shin, Soochul; Hyun, Kwangbeom; Lee, Jinwoo; Joo, Dongwon; Kulikowicz, Tomasz; Bohr, Vilhelm A; Kim, Jaehoon; Hohng, Sungchul

Hypothermic Protection in Neocortex Is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein Rbfox3/NeuN in Neonatal Hypoxic-Ischemic Male Piglets

新皮层低温保护具有地形性和层状性,不会减轻癫痫发作,但能部分挽救新生缺氧缺血雄性仔猪中RNA剪接蛋白Rbfox3/NeuN耗竭的神经元。

Primiani, Christopher T; Lee, Jennifer K; O'Brien, Caitlin E; Chen, May W; Perin, Jamie; Kulikowicz, Ewa; Santos, Polan; Adams, Shawn; Lester, Bailey; Rivera-Diaz, Natalia; Olberding, Valerie; Niedzwiecki, Mark V; Ritzl, Eva K; Habela, Christa W; Liu, Xiuyun; Yang, Zeng-Jin; Koehler, Raymond C; Martin, Lee J

Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation

利用经鼻空气流对儿童复苏进行快速、选择性和均匀的脑部降温

Koehler, Raymond C; Reyes, Michael; Hopkins, C Danielle; Armstrong, Jillian S; Cao, Suyi; Kulikowicz, Ewa; Lee, Jennifer K; Tandri, Harikrishna