日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates.

在非人灵长类动物中快速诱导产生针对 HIV-1 Env V3 糖表位的 Asn332 糖基化非依赖性中和抗体。

Relano-Rodriguez Ignacio, Du Jianqiu, Lin Zi Jie, Kerwin Margaret, Tarquis-Medina Marta, Urbano Eduardo, Cui Jiayan, Watkins Meagan, Lavine Christy L, Zhao Peng, Habib Rumi, Agostino Colby, Ghosh Sukanya, Park Joyce, Boroughs Caroline, Walsh Agnes A, Melo Mariane B, Shukla Niharika, Shaw George M, Hahn Beatrice H, Irvine Darrell J, Wells Lance, Weiner David B, Seaman Michael S, Kulp Daniel W, Veazey Ronald S, Pallesen Jesper, Escolano Amelia

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

纳米颗粒免疫佐剂复合物增强生发中心对疫苗的反应

Tursi, Nicholas J; Agostino, Colby J; Huang, Jinwei; Kannan, Toshitha; Laenger, Niklas; Londregan, Jennifer; Lederer, Katlyn; Helble, Michaela; Bedanova, Nicole; Livingston, Cory; Gary, Ebony N; McCanna, Madison; Medina, Marta Tarquis; Habib, Rumi; Relaño, Ignacio Rodriguez; Maillard, Ivan; Patel, Ami; Allman, David; Kossenkov, Andrew; Escolano, Amelia; Kulp, Daniel W; Weiner, David B

Immune-focused RBD nanoparticles induce cross-reactive, RBS-directed responses capable of variant-resistant SARS-CoV-2 neutralization

免疫靶向RBD纳米颗粒可诱导交叉反应性、RBS导向的免疫应答,从而实现对SARS-CoV-2变异株的中和作用

Konrath, Kylie M; Liaw, Kevin; Tursi, Nicholas J; McCanna, Madison E; Warner, Bryce M; Gary, Ebony N; Zhu, Xizhou; Livingston, Cory; Monastra, Cara; Frase, Drew; Chokkalingam, Neethu; Huynh, Alana; Shupin, Nicholas; Bayruns, Kelly; Kriete, Sinja; Kim, Amber; Park, Joyce; Vendramelli, Robert; Truong, Thang; Tierney, Kevin; Azaransky, Kimberly; Moffat, Estella; Embury-Hyatt, Carissa; Beer, Lynn A; Solanke, Oreoluwa; Walker, Susanne N; Kalia, Richa; Tang, Hsin-Yao; Humeau, Laurent M P F; Smith, Trevor R F; Kobasa, Darwyn; Weiner, David B; Kulp, Daniel W

Structure and sequence engineering approaches to improve in vivo expression of nucleic acid-delivered antibodies.

通过结构和序列工程方法提高核酸递送抗体的体内表达

Helble Michaela, Chu Jacqueline, Flowers Kaitlyn, Trachtman Abigail R, Huynh Alana, Kim Amber, Shupin Nicholas, Hojecki Casey E, Gary Ebony N, Solieva Shahlo, Parzych Elizabeth M, Weiner David B, Kulp Daniel W, Patel Ami

Machine learning enables de novo multiepitope design of Plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

机器学习能够对恶性疟原虫环子孢子蛋白进行从头多表位设计,以靶向三聚体L9抗体

Nelson, J Andrew D; Garfinkle, Samuel E; Lin, Zi Jie; Park, Joyce; Kim, Amber J; Bayruns, Kelly; McCanna, Madison E; Konrath, Kylie M; Agostino, Colby J; Kulp, Daniel W; Odom John, Audrey R; Pallesen, Jesper

Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.

短暂的聚糖屏障减少可诱导 SHIV 感染的猕猴产生 CD4 结合位点广谱中和抗体

Morris Daniel J, Gorman Jason, Zhou Tongqing, Lora Jinery, Connell Andrew J, Li Hui, Liu Weimin, Roark Ryan S, Campion Mary S, Carey John W, Habib Rumi, Li Yingying, Martella Christian L, Park Younghoon, Singh Ajay, Sowers Kirsten J, Teng I-Ting, Wang Shuyi, Chohan Neha, Ding Wenge, Lauer Craig, Lewis Emily, Mason Rosemarie D, Rando Juliette M, Peyton Lowrey, Schramm Chaim A, Wagh Kshitij, Korber Bette, Seaman Michael S, Douek Daniel C, Haynes Barton F, Kulp Daniel W, Roederer Mario, Hahn Beatrice H, Kwong Peter D, Shaw George M

Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV.

HPV稳定化、扩增表位纳米颗粒疫苗的结构工程

Helble Michaela, Zhu Xizhou, Bhojnagarwala Pratik S, Liaw Kevin, Gao Yangcheng, Kim Amber, Bayruns Kelly, McCanna Madison E, Park Joyce, Konrath Kylie M, Garfinkle Sam, Brysgel Taylor, Weiner David B, Kulp Daniel W

Machine learning enables de novo multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

机器学习技术能够从头设计恶性疟原虫环子孢子蛋白的多表位,以靶向三聚体L9抗体

Nelson, J Andrew D; Garfinkle, Samuel E; Lin, Zi Jie; Park, Joyce; Kim, Amber J; Bayruns, Kelly; McCanna, Madison E; Konrath, Kylie M; Agostino, Colby J; Kulp, Daniel W; John, Audrey R Odom; Pallesen, Jesper

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

对人类抗体库的深度挖掘发现了可通过疫苗接种靶向的常见且遗传多样性丰富的CDRH3拓扑结构

Habib, Rumi; Solieva, Shahlo O; Lin, Zi Jie; Ghosh, Sukanya; Bayruns, Kelly; Singh, Maya; Agostino, Colby J; Tursi, Nicholas J; Sowers, Kirsten J; Huang, Jinwei; Roark, Ryan S; Purwar, Mansi; Park, Younghoon; Ayyanathan, Kasirajan; Li, Hui; Carey, John W; Kim, Amber; Park, Joyce; McCanna, Madison E; Skelly, Ashwin N; Chokkalingam, Neethu; Kriete, Sinja; Shupin, Nicholas; Huynh, Alana; Walker, Susanne; Sadeesh, Roopak; Laenger, Niklas; Du, Jianqiu; Cui, Jiayan; Patel, Ami; Escolano, Amelia; Kwong, Peter D; Shapiro, Lawrence; Bowman, Gregory R; Hahn, Beatrice H; Shaw, George M; Weiner, David B; Pallesen, Jesper; Kulp, Daniel W