日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

μ-阿片受体正向变构调节剂的发现和动态药理学

O'Brien, Evan S; Wang, Junzheng; Tanguturi, Parthasaradhireddy; Li, Mengchu; White, Elizabeth; Shiimura, Yuki; Paul, Barnali; Appourchaux, Kevin; Kumar, Kaavya Krishna; Huang, Weijiao; Majumdar, Susruta; Traynor, John R; Streicher, John M; Chen, Chunlai; Kobilka, Brian K

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

针对副作用较小的1型大麻素受体激动剂的大型化合物库对接

Tummino, Tia A; Iliopoulos-Tsoutsouvas, Christos; Braz, Joao M; O'Brien, Evan S; Stein, Reed M; Craik, Veronica; Tran, Ngan K; Ganapathy, Suthakar; Liu, Fangyu; Shiimura, Yuki; Tong, Fei; Ho, Thanh C; Radchenko, Dmytro S; Moroz, Yurii S; Rosado, Sian Rodriguez; Bhardwaj, Karnika; Benitez, Jorge; Liu, Yongfeng; Kandasamy, Herthana; Normand, Claire; Semache, Meriem; Sabbagh, Laurent; Glenn, Isabella; Irwin, John J; Kumar, Kaavya Krishna; Makriyannis, Alexandros; Basbaum, Allan I; Shoichet, Brian K

Viewing rare conformations of the β(2) adrenergic receptor with pressure-resolved DEER spectroscopy

利用压力分辨双电子自旋共振光谱法观察β(2)肾上腺素能受体的罕见构象

Lerch, Michael T; Matt, Rachel A; Masureel, Matthieu; Elgeti, Matthias; Kumar, Kaavya Krishna; Hilger, Daniel; Foys, Bryon; Kobilka, Brian K; Hubbell, Wayne L

Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells

LGR5的结构和功能:一种神秘的G蛋白偶联受体,可标记干细胞

Kumar, Kaavya Krishna; Burgess, Antony W; Gulbis, Jacqueline M

Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus

血红蛋白-IsdH复合物的结构揭示了金黄色葡萄球菌捕获铁的分子基础

Dickson, Claire F; Kumar, Kaavya Krishna; Jacques, David A; Malmirchegini, G Reza; Spirig, Thomas; Mackay, Joel P; Clubb, Robert T; Guss, J Mitchell; Gell, David A

The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface

金黄色葡萄球菌血红蛋白结合域与α-血红蛋白形成的复合物结构揭示了难以捉摸的α-血红蛋白二聚化界面。

Kumar, Kaavya Krishna; Jacques, David A; Guss, J Mitchell; Gell, David A