日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection.

核旁斑的凝聚是通过 TDP-43 聚合控制的,并且与神经保护有关。

Hodgson Rachel E, Huang Wan-Ping, Lang Ruaridh, Kumar Vedanth, An Haiyan, Stender Emil G P, Chalakova Zhaklin P, Driver Mark D, Sanchez Avila Anna, Ellis Brittany C S, Day Emily, Rayment Jessica A, Baeg Kyungmin, Strange Andrew, Moll Tobias, Wright Gareth S A, van Vugt Joke J F A, Allen Scott P, Locker Nicolas, Pitout Ianthe, Fletcher Susan, Onck Patrick R, Duss Olivier, Cooper-Knock Johnathan, Shelkovnikova Tatyana A

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis

M102 可激活 NRF2 和 HSF1 转录因子通路,并在肌萎缩侧索硬化症的细胞和动物模型中发挥神经保护作用。

Keerie, Amy F; Martins, Raquel Rua; Allen, Chloe F; Bowden, Katie; Al Mashhadi, Sufana; Marlow, Thomas; Myszczynska, Monika; Thakur, Nikitha; Beal, Selina N; Shaw, Allan; Suresh, Shivani; McKinnon, Scott N; Cooper-Knock, Johnathan; West, Ryan J H; Bonsall, Sam; Daniel, Alex; Wells, Tyler; Kumar, Vedanth; Ellis, Brittany C S; Higgins, Maureen; Dinkova-Kostova, Albena T; Shelkovnikova, Tatyana A; Kalfus, Ira N; Shan, Ning; Shaw, Pamela J; Ferraiuolo, Laura; Mead, Richard J

M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.

M6A依赖的RNA凝聚是FUS自身调节的基础,可用于ALS治疗的开发

Huang Wan-Ping, Kumar Vedanth, Yap Karen, An Haiyan, John Sabin J, Hodgson Rachel E, Avila Anna Sanchez, Day Emily, Ellis Brittany C S, Chung Tek Hong, Lord Jenny, Müller-McNicoll Michaela, Makeyev Eugene V, Shelkovnikova Tatyana A