Deletion of Megalin in Kidney Tubular Epithelium Up-Regulates TGFβ1 Signaling, Aggravates Ischemia/Reperfusion Kidney Injury, and Accelerates the Progression to Chronic Kidney Disease.
肾小管上皮细胞中巨蛋白的缺失会上调 TGFβ1 信号传导,加剧缺血/再灌注肾损伤,并加速慢性肾病的进展。
期刊:American Journal of Pathology
影响因子:3.6
doi:10.1016/j.ajpath.2025.11.011
Li Qingtian, Li Jeffery, Tan Li, Holliday Michael, Ji Emily, Thomas Sandhya, Cheng Jizhong, Kumar M N V Ravi, Sheikh-Hamad David