Kunos相关文献与解析，生知库 | 链接生命科学的每一步

Herrerias, Alexa; Oliverio, Anna; Dvorácskó, Szabolcs; Thyagarajan, Arthi; Chedester, Lee; Liu, Jie; Cinar, Resat; Iyer, Malliga R; Kunos, George; Godlewski, Grzegorz

信号转导

神经科学

发表日期：2026

文献求助收藏

Hepatic Aquaporin 8 Promotes Alcohol Consumption and Ameliorates Alcohol-Induced Liver Injury by Facilitating Acetaldehyde Excretion.

肝脏水通道蛋白 8 通过促进乙醛排泄来促进酒精摄入并减轻酒精引起的肝损伤。

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.122713

Chen Cheng, Lin Yu-Hong, Feng Dechun, Guan Yukun, Fu Yaojie, Wang Yang, Maccioni Luca, Seyhan Deniz, Yao Tiantian, Wei Shoupeng, Zhang Li, Kunos George, Mackowiak Bryan, Gao Bin

肝损伤

发表日期：2026

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Monlunabant in adults with obesity and metabolic syndrome: Open-label extension of a phase 2a trial

Monlunabant治疗肥胖和代谢综合征成人：一项2a期试验的开放标签扩展研究

期刊:Diabetes Obesity & Metabolism

影响因子:5.7

doi:10.1111/dom.70580

Knop, Filip K; Kunos, George; Dicker, Dror; Paquette, Jean-Sebastien; Aronne, Louis; Birkhan, Oscar; Frenkel, Ofir; Holst-Hansen, Thomas; Lalonde, Karine; Crater, Glenn

A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

一项针对局部晚期头颈部鳞状细胞癌患者的 1 期研究，评估 berzosertib (M6620, VX-970) 与顺铂和放射治疗的疗效 (ETCTN 9950)

期刊:Cancer

影响因子:5.1

doi:10.1002/cncr.70346

Bhatia, Aarti; Chen, Zhengjia; Zhang, Yuji; Bruce, Justine Yang; Arnold, Susanne; Kaur, Varinder; Riess, Jonathan W; Fenton, Moon; Burtness, Barbara; Saba, Nabil F; Tara, Harold; Steuer, Conor E; Shin, Dong M; Wasp, Garrett; Davis, Thomas H; Patel, Malini; Schmitz, John C; Bhateja, Priyanka; Diavolitsis, Virginia; Zandberg, Dan P; Mitchell, Darrion L; Kiesel, Brian F; Kunos, Charles; Gore, Steven D; Carducci, Michael; Beumer, Jan H; Owonikoko, Taofeek K

Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial

莫鲁那班治疗肥胖和代谢综合征成人患者的疗效和安全性：一项双盲、随机、安慰剂对照的2a期试验

期刊:Lancet Diabetes & Endocrinology

影响因子:41.8

doi:10.1016/S2213-8587(25)00216-5

Knop, Filip K; Kunos, George; Dicker, Dror; Paquette, Jean-Sebastien; Aronne, Louis; Frenkel, Ofir; Holst-Hansen, Thomas; Lalonde, Karine; Lee, Jisoo; Crater, Glenn

Opposite regulation of intestinal and intrahepatic CD8(+) T cells controls alcohol-associated liver disease progression

肠道和肝内CD8(+) T细胞的相反调控控制着酒精相关性肝病的进展。

期刊:Gut

影响因子:25.8

doi:10.1136/gutjnl-2024-334412

Maccioni, Luca; Guan, Yukun; Kim, Mariia; Parra, Maria A; Peiffer, Brandon; Fu, Yaojie; Wang, Yang; Lin, Yu-Hong; Mackowiak, Bryan; Feng, Dechun; Cameron, Andrew; Sun, Zhaoli; Kunos, George; Stärkel, Peter; Gao, Bin

Hepatic CB1 receptor signaling triggers G(i/o)α-mediated lipolysis in lean mice but G(s)α-mediated lipogenesis in obese mice

肝脏CB1受体信号传导在瘦小鼠中触发G(i/o)α介导的脂肪分解，但在肥胖小鼠中触发G(s)α介导的脂肪生成。

期刊:Metabolism-Clinical and Experimental

影响因子:11.9

doi:10.1016/j.metabol.2025.156308

Liu, Jie; Oliverio, Anna; Godlewski, Grzegorz; Kočvarová, Radka; Arif, Muhammad; Basu, Abhishek; Guan, Yukun; Feng, Dechun; Puhl, Henry L; Iyer, Malliga R; Cinar, Resat; Gao, Bin; Tam, Joseph; Kunos, George

Exacerbated cardiac dysfunction from combined alcohol binge and synthetic cannabinoid use

酒精滥用和合成大麻素使用共同导致心脏功能障碍加剧。

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2025.118053

Paloczi, Janos; Gunduz-Cinar, Ozge; Yokus, Burhan; Paes-Leme, Bruno; Haskó, György; Kunos, George; Holmes, Andrew; Pacher, Pal

发表日期：2025

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Incorporation of triapine (T) to cisplatin chemoradiation (CRT) for locally advanced cervical and vaginal cancer: Results from NRG-GY006, a phase III randomized trial

将三嗪（T）加入顺铂放化疗（CRT）治疗局部晚期宫颈癌和阴道癌：NRG-GY006 III期随机试验的结果

期刊:Gynecologic Oncology

影响因子:4.1

doi:10.1016/j.ygyno.2025.03.007

Leath, Charles A 3rd; Deng, Wei; Mell, Loren K; Richardson, Debra L; Walker, Joan L; Holman, Laura L; Lea, Jayanthi S; Amarnath, Sudha R; Santos-Reyes, Luis Javier; Arend, Rebecca C; Mayadev, Jyoti; Jegadeesh, Naresh; DiSilvestro, Paul; Chon, Hye Sook; Ghamande, Sharad A; Gao, Lei; Albuquerque, Kevin; Chino, Junzo P; Donnelly, Eric; Feddock, Jonathan M; Lowenstein, Jessica; Quick, Allison M; Kunos, Charles M; MacKay, Helen; Aghajanian, Carol; Monk, Bradley J

Designing theranostic radiopharmaceutical trials for uterine cervix cancer

设计用于治疗子宫颈癌的放射性药物诊疗一体化试验

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2025.1708720

Fabian, Denise; Buffington, Molly E; Cagle, Brianna S; Keefe, Steve M; Schultz, Michael K; Kunos, Charles A

CB(1) receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice

迷走神经传入神经元亚群上的CB(1)受体调节小鼠的自愿性乙醇摄入量。

Hepatic Aquaporin 8 Promotes Alcohol Consumption and Ameliorates Alcohol-Induced Liver Injury by Facilitating Acetaldehyde Excretion.

肝脏水通道蛋白 8 通过促进乙醛排泄来促进酒精摄入并减轻酒精引起的肝损伤。

Monlunabant in adults with obesity and metabolic syndrome: Open-label extension of a phase 2a trial

Monlunabant治疗肥胖和代谢综合征成人：一项2a期试验的开放标签扩展研究

A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

一项针对局部晚期头颈部鳞状细胞癌患者的 1 期研究，评估 berzosertib (M6620, VX-970) 与顺铂和放射治疗的疗效 (ETCTN 9950)

Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial

莫鲁那班治疗肥胖和代谢综合征成人患者的疗效和安全性：一项双盲、随机、安慰剂对照的2a期试验

Opposite regulation of intestinal and intrahepatic CD8(+) T cells controls alcohol-associated liver disease progression

肠道和肝内CD8(+) T细胞的相反调控控制着酒精相关性肝病的进展。

Hepatic CB1 receptor signaling triggers G(i/o)α-mediated lipolysis in lean mice but G(s)α-mediated lipogenesis in obese mice

肝脏CB1受体信号传导在瘦小鼠中触发G(i/o)α介导的脂肪分解，但在肥胖小鼠中触发G(s)α介导的脂肪生成。

Exacerbated cardiac dysfunction from combined alcohol binge and synthetic cannabinoid use

酒精滥用和合成大麻素使用共同导致心脏功能障碍加剧。

Incorporation of triapine (T) to cisplatin chemoradiation (CRT) for locally advanced cervical and vaginal cancer: Results from NRG-GY006, a phase III randomized trial

将三嗪（T）加入顺铂放化疗（CRT）治疗局部晚期宫颈癌和阴道癌：NRG-GY006 III期随机试验的结果

Designing theranostic radiopharmaceutical trials for uterine cervix cancer

设计用于治疗子宫颈癌的放射性药物诊疗一体化试验