日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis of CSN-mediated SCF deneddylation

CSN介导的SCF去内切酶化的结构基础

Ding, Shan; Clapperton, Julie A; Mäeots, Märt-Erik; Kunzelmann, Simone; Shaaban, Mohammed; Enchev, Radoslav I

Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN.

抗病毒核糖核酸内切酶 KHNYN 的延伸 diKH 结构域的结构和功能表征

Youle Rebecca L, Lista María José, Bouton Clement, Kunzelmann Simone, Wilson Harry, Cottee Matthew A, Purkiss Andrew G, Morris Elizabeth R, Neil Stuart J D, Taylor Ian A, Swanson Chad M

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

SAMHD1催化的平台导向变构和四级结构动力学

Acton, Oliver J; Sheppard, Devon; Kunzelmann, Simone; Caswell, Sarah J; Nans, Andrea; Burgess, Ailidh J O; Kelly, Geoff; Morris, Elizabeth R; Rosenthal, Peter B; Taylor, Ian A

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

靶向核苷酸补救因子DNPH1可使BRCA缺陷细胞对PARP抑制剂敏感

Fugger, Kasper; Bajrami, Ilirjana; Silva Dos Santos, Mariana; Young, Sarah Jane; Kunzelmann, Simone; Kelly, Geoff; Hewitt, Graeme; Patel, Harshil; Goldstone, Robert; Carell, Thomas; Boulton, Simon J; MacRae, James; Taylor, Ian A; West, Stephen C

Structural characterisation of the Chaetomium thermophilum Chl1 helicase

嗜热毛壳菌 Chl1 解旋酶的结构表征

Hodáková, Zuzana; Nans, Andrea; Kunzelmann, Simone; Mehmood, Shahid; Taylor, Ian; Uhlmann, Frank; Cherepanov, Peter; Singleton, Martin R

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

SAMHD1抑制剂复合物的晶体结构揭示了水介导的dNTP水解机制

Morris Elizabeth R, Caswell Sarah J, Kunzelmann Simone, Arnold Laurence H, Purkiss Andrew G, Kelly Geoff, Taylor Ian A

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1

HIV-1限制因子SAMHD1三磷酸水解酶活性的连续酶偶联测定

Arnold, Laurence H; Kunzelmann, Simone; Webb, Martin R; Taylor, Ian A

Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism

氨基糖苷磷酸转移酶(3')-IIIa的瞬态动力学揭示了抗生素耐药机制中的潜在药物靶点。

Lallemand, Perrine; Leban, Nadia; Kunzelmann, Simone; Chaloin, Laurent; Serpersu, Engin H; Webb, Martin R; Barman, Tom; Lionne, Corinne

Detecting intramolecular conformational dynamics of single molecules in short distance range with subnanometer sensitivity

以亚纳米级灵敏度检测短距离范围内单个分子的分子内构象动力学。

Zhou, Ruobo; Kunzelmann, Simone; Webb, Martin R; Ha, Taekjip

Fluorescence detection of GDP in real time with the reagentless biosensor rhodamine-ParM

利用无试剂生物传感器罗丹明-ParM实时荧光检测GDP

Kunzelmann, Simone; Webb, Martin R