日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

将高通量蛋白酶酶学与病毒复制相结合,揭示了病毒适应性的生化限制。

Aidlen, Dylan; Vo, William Vinh Thanh; Young, Nicholas J; Rosecrans, Julia; Kurianowicz, Anna; Chuo, Shih-Wei; Asper, Garrison P R; Anderson, Dashiell; Posner, Jacob A; Muir, Duncan F; Freitas, Nicholas; Ott, Melanie; Craik, Charles S; Taha, Taha Y; Pinney, Margaux M

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

携带 NSP6 中 L260F 突变的近期 SARS-CoV-2 变种增强了 RNA 复制和致病性

Taha Taha Y, Ezzatpour Shahrzad, Hayashi Jennifer M, Ye Chengjin, Zapatero-Belinchón Francisco J, Rosecrans Julia A, Kimmerly Gabriella R, Chen Irene P, Walcott Keith, Kurianowicz Anna, Jorgens Danielle M, Chaplin Natalie R, Choi Annette, Buchholz David W, Sahler Julie, Hilt Zachary T, Imbiakha Brian, Vagi-Szmola Cecilia, Montano Mauricio, Stevenson Erica, Gordon Martin, Swaney Danielle L, Krogan Nevan J, Whittaker Gary R, Martinez-Sobrido Luis, Aguilar Hector C, Ott Melanie