Kursawe Romy相关文献与解析，生知库 | 链接生命科学的每一步

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.

LONP1 对线粒体蛋白折叠的调控为 2 型糖尿病中 β 细胞功能衰竭提供了见解

Li Jin, Deng Yamei, Gasser Marie, Zhu Jie, Walker Emily M, Sidarala Vaibhav, Reck Emma C, Hubers Dre L, Pasmooij Mabelle B, Shin Chun-Shik, Bandesh Khushdeep, Motakis Eftyhmios, Nargund Siddhi, Kursawe Romy, Basrur Venkatesha, Nesvizhskii Alexey I, Stitzel Michael L, Chan David C, Rutter Guy A, Soleimanpour Scott A

细胞生物学

From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes

从人类到小鼠再回到人类：2型糖尿病胰岛功能障碍的遗传和基因组故事

期刊:Annual Review of Genetics

影响因子:8.6

doi:10.1146/annurev-genet-020525-114513

Kursawe, Romy; Bandesh, Khushdeep; Krishnan, Sai Nivedita; Liu, Kevin S; Bhuiyan, Redwan M; Stitzel, Michael L

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β -cell gene expression defects

对2型糖尿病中人类胰岛细胞类型特异性改变的单细胞解码揭示了遗传和状态驱动的β细胞基因表达缺陷的汇聚。

期刊:

影响因子:

doi:10.1101/2025.01.17.633590

Bandesh, Khushdeep; Motakis, Efthymios; Nargund, Siddhi; Kursawe, Romy; Selvam, Vijay; Bhuiyan, Redwan M; Eryilmaz, Giray Naim; Krishnan, Sai Nivedita; Spracklen, Cassandra N; Ucar, Duygu; Stitzel, Michael L

Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity

肥胖青少年原发性胰岛素分泌过多的标志是脂肪组织分布、细胞形态和功能的改变

期刊:Diabetes

影响因子:7.5

doi:10.2337/db23-0450

Tricò, Domenico; Chiriacò, Martina; Nouws, Jessica; Vash-Margita, Alla; Kursawe, Romy; Tarabra, Elena; Galderisi, Alfonso; Natali, Andrea; Giannini, Cosimo; Hellerstein, Marc; Ferrannini, Ele; Caprio, Sonia

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

AMULET：一种基于读取计数的新型方法，可从单细胞核ATAC-seq数据中有效检测多重突变体。

期刊:Genome Biology

影响因子:9.4

doi:10.1186/s13059-021-02469-x

Thibodeau, Asa; Eroglu, Alper; McGinnis, Christopher S; Lawlor, Nathan; Nehar-Belaid, Djamel; Kursawe, Romy; Marches, Radu; Conrad, Daniel N; Kuchel, George A; Gartner, Zev J; Banchereau, Jacques; Stitzel, Michael L; Cicek, A Ercument; Ucar, Duygu

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

皮下脂肪组织中体内脂质通量和细胞动力学的改变与肥胖少女不良的脂肪分布模式有关

期刊:Diabetes

影响因子:7.5

doi:10.2337/db18-1162

Nouws, Jessica; Fitch, Mark; Mata, Mariana; Santoro, Nicola; Galuppo, Brittany; Kursawe, Romy; Narayan, Deepak; Vash-Margita, Alla; Pierpont, Bridget; Shulman, Gerald I; Hellerstein, Marc; Caprio, Sonia

Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function

多组学分析揭示了人类胰岛β细胞特性和功能相关的顺式调控网络

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2018.12.083

Lawlor, Nathan; Márquez, Eladio J; Orchard, Peter; Narisu, Narisu; Shamim, Muhammad Saad; Thibodeau, Asa; Varshney, Arushi; Kursawe, Romy; Erdos, Michael R; Kanke, Matt; Gu, Huiya; Pak, Evgenia; Dutra, Amalia; Russell, Sheikh; Li, Xingwang; Piecuch, Emaly; Luo, Oscar; Chines, Peter S; Fuchbserger, Christian; Sethupathy, Praveen; Aiden, Aviva Presser; Ruan, Yijun; Aiden, Erez Lieberman; Collins, Francis S; Ucar, Duygu; Parker, Stephen C J; Stitzel, Michael L

Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation

青少年肥胖与胰岛素抵抗：异位脂肪堆积和脂肪组织炎症的作用

期刊:Gastroenterology

影响因子:25.1

doi:10.1053/j.gastro.2016.12.051

Caprio, Sonia; Perry, Rachel; Kursawe, Romy

炎症

炎症/感染

Immunology/Inflammation

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

胰岛基因表达和2型糖尿病的遗传调控特征

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1621192114

Varshney, Arushi; Scott, Laura J; Welch, Ryan P; Erdos, Michael R; Chines, Peter S; Narisu, Narisu; Albanus, Ricardo D'O; Orchard, Peter; Wolford, Brooke N; Kursawe, Romy; Vadlamudi, Swarooparani; Cannon, Maren E; Didion, John P; Hensley, John; Kirilusha, Anthony; Bonnycastle, Lori L; Taylor, D Leland; Watanabe, Richard; Mohlke, Karen L; Boehnke, Michael; Collins, Francis S; Parker, Stephen C J; Stitzel, Michael L

Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes

Tet2调节与糖尿病β细胞死亡和自身免疫相关的内质网应激反应

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.

LONP1 对线粒体蛋白折叠的调控为 2 型糖尿病中 β 细胞功能衰竭提供了见解

From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes

从人类到小鼠再回到人类：2型糖尿病胰岛功能障碍的遗传和基因组故事

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β -cell gene expression defects

对2型糖尿病中人类胰岛细胞类型特异性改变的单细胞解码揭示了遗传和状态驱动的β细胞基因表达缺陷的汇聚。

Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity

肥胖青少年原发性胰岛素分泌过多的标志是脂肪组织分布、细胞形态和功能的改变

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

AMULET：一种基于读取计数的新型方法，可从单细胞核ATAC-seq数据中有效检测多重突变体。

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

皮下脂肪组织中体内脂质通量和细胞动力学的改变与肥胖少女不良的脂肪分布模式有关

Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function

多组学分析揭示了人类胰岛β细胞特性和功能相关的顺式调控网络

Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation

青少年肥胖与胰岛素抵抗：异位脂肪堆积和脂肪组织炎症的作用

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

胰岛基因表达和2型糖尿病的遗传调控特征