日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19

应用CiPA方法评估一些在COVID-19第一波疫情期间超适应症使用抗疟药的心脏致心律失常风险

Delaunois, Annie; Abernathy, Matthew; Anderson, Warren D; Beattie, Kylie A; Chaudhary, Khuram W; Coulot, Julie; Gryshkova, Vitalina; Hebeisen, Simon; Holbrook, Mark; Kramer, James; Kuryshev, Yuri; Leishman, Derek; Lushbough, Isabel; Passini, Elisa; Redfern, Will S; Rodriguez, Blanca; Rossman, Eric I; Trovato, Cristian; Wu, Caiyun; Valentin, Jean-Pierre

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

开发和验证一种高效且特异性的CLC-2氯离子通道抑制剂

Koster, Anna K; Reese, Austin L; Kuryshev, Yuri; Wen, Xianlan; McKiernan, Keri A; Gray, Erin E; Wu, Caiyun; Huguenard, John R; Maduke, Merritt; Du Bois, J

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

在CiPA计划下评估用于预测心律失常风险的计算机模拟机制模型

Li, Zhihua; Ridder, Bradley J; Han, Xiaomei; Wu, Wendy W; Sheng, Jiansong; Tran, Phu N; Wu, Min; Randolph, Aaron; Johnstone, Ross H; Mirams, Gary R; Kuryshev, Yuri; Kramer, James; Wu, Caiyun; Crumb, William J Jr; Strauss, David G

Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I/II mode of action

拟除虫菊酯类杀虫剂与联苯菊酯的神经毒性研究表明,其作用机制为I/II型混合型。

Gammon, Derek W; Liu, Zhiwei; Chandrasekaran, Appavu; El-Naggar, Shaaban F; Kuryshev, Yuri A; Jackson, Sharon

Electrophysiology-Based Assays to Detect Subtype-Selective Modulation of Human Nicotinic Acetylcholine Receptors

基于电生理学的检测人类尼古丁乙酰胆碱受体亚型选择性调节的检测方法

Kirsch, Glenn E; Fedorov, Nikolai B; Kuryshev, Yuri A; Liu, Zhiqi; Armstrong, Lucas C; Orr, Michael S

Evaluating state dependence and subtype selectivity of calcium channel modulators in automated electrophysiology assays

在自动化电生理检测中评估钙通道调节剂的状态依赖性和亚型选择性

Kuryshev, Yuri A; Brown, Arthur M; Duzic, Emir; Kirsch, Glenn E