Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
动态成像显示肿瘤中 LDH 抑制可导致体内代谢快速重编程,并对联合疗法产生敏感性
期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2020.01.039
Oshima Nobu, Ishida Ryo, Kishimoto Shun, Beebe Kristin, Brender Jeffrey R, Yamamoto Kazutoshi, Urban Daniel, Rai Ganesha, Johnson Michelle S, Benavides Gloria, Squadrito Giuseppe L, Crooks Dan, Jackson Joseph, Joshi Abhinav, Mott Bryan T, Shrimp Jonathan H, Moses Michael A, Lee Min-Jung, Yuno Akira, Lee Tobie D, Hu Xin, Anderson Tamara, Kusewitt Donna, Hathaway Helen H, Jadhav Ajit, Picard Didier, Trepel Jane B, Mitchell James B, Stott Gordon M, Moore William, Simeonov Anton, Sklar Larry A, Norenberg Jeffrey P, Linehan W Marston, Maloney David J, Dang Chi V, Waterson Alex G, Hall Matthew, Darley-Usmar Victor M, Krishna Murali C, Neckers Leonard M