日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex

TNF-α 对 PRKDC 的非常规激活:揭示其作为 DNA-PK 复合物的一部分在 Th1 介导的炎症中除 DNA 修复之外的关键作用

Mohamed A Ghonim #, Jihang Ju #, Kusma Pyakurel #, Salome V Ibba, Mai M Abouzeid, Hamada F Rady, Shigemi Matsuyama, Luis Del Valle, A Hamid Boulares

Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

硫酸化非抗凝肝素通过调节 IL-4/信号转导和转录激活因子 6/Janus 激酶 1 通路阻断 Th2 诱发的哮喘

Mohamed A Ghonim, Jeffrey Wang, Salome V Ibba, Hanh H Luu, Kusma Pyakurel, Ilyes Benslimane, Shaker Mousa, A Hamid Boulares

Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity

诱导型一氧化氮合酶作为过敏原诱发的气道高反应性治疗靶点的潜力:与一氧化氮水平和 PARP 活性的关键联系

Salome' V Ibba, Mohamed A Ghonim, Kusma Pyakurel, Matthew R Lammi, Anil Mishra, A Hamid Boulares

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency

DNA 依赖性蛋白激酶抑制剂可阻断小鼠哮喘,并调节人类内皮细胞和 CD4⁺ T 细胞功能,且不会引起严重的联合免疫缺陷

Mohamed A Ghonim, Kusma Pyakurel, Jihang Ju, Paulo C Rodriguez, Matthew R Lammi, Christian Davis, Mohammad Q Abughazleh, Moselhy S Mansy, Amarjit S Naura, A Hamid Boulares

PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice

PARP 在人类哮喘中被激活,而奥拉帕尼抑制 PARP 可阻止小鼠因屋尘螨诱发的疾病

Mohamed A Ghonim, Kusma Pyakurel, Salome V Ibba, Jeffrey Wang, Paulo Rodriguez, Amir A Al-Khami, Matthew R Lammi, Hogyoung Kim, Arnold H Zea, Christian Davis, Samuel Okpechi, Dorota Wyczechowska, Kamel Al-Ghareeb, Moselhy S Mansy, Augusto Ochoa, Amarjit S Naura, A Hamid Boulares