日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models

STX-721 是一种共价 EGFR/HER2 外显子 20 抑制剂,它利用外显子 20 突变体的动态蛋白状态,并在人类癌症模型中实现了独特的突变选择性。

Raymond A Pagliarini,Jack A Henderson,Benjamin C Milgram,Deanna R Borrelli,Natasja Brooijmans,Brendan J Hilbert,Michael R Huff,Takahiro Ito,Gregory V Kryukov,Brendon Ladd,Brent R Martin,Hashim Motiwala,Erin O'Hearn,Chia-Feng Tsai,Weixue Wang,Justine Bellier,Luke Boland,Sarah Clark,Emily Hensley,Aaron N Hata,Petr Kuzmic,Angel Guzman-Perez,Erica L Jackson,Darrin D Stuart

The impact of the COVID-19 pandemic on adverse fetal outcomes: A cross-sectional study

COVID-19 大流行对不良胎儿结局的影响:一项横断面研究

Dagelić, Andrea; Mulic, Emma; Kuzmic Prusac, Ivana; Zekic Tomas, Sandra

Precoce and opposite response of proteasome activity after acute or chronic exposure of C. elegans to γ-radiation

秀丽隐杆线虫急性或慢性暴露于γ射线后蛋白酶体活性的早衰和相反反应

Dubois, Cécile; Lecomte, Catherine; Ruys, Sébastien Pyr Dit; Kuzmic, Mira; Della-Vedova, Claire; Dubourg, Nicolas; Galas, Simon; Frelon, Sandrine

Carbonylation accumulation of the Hypsibius exemplaris anhydrobiote reveals age-associated marks

Hypsibius exemplaris 脱水生物体的羰基化积累揭示了与年龄相关的特征

Kuzmic, Mira; Richaud, Myriam; Cuq, Pierre; Frelon, Sandrine; Galas, Simon

Analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate

双结构域磷酸糖基转移酶的分析揭示了具有共价酶中间体的乒乓机制

Debasis Das, Petr Kuzmic, Barbara Imperiali

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

共价EGFR抑制剂分析揭示了可逆相互作用对药物效力和耐药机制的重要性

Schwartz, Phillip A; Kuzmic, Petr; Solowiej, James; Bergqvist, Simon; Bolanos, Ben; Almaden, Chau; Nagata, Asako; Ryan, Kevin; Feng, Junli; Dalvie, Deepak; Kath, John C; Xu, Meirong; Wani, Revati; Murray, Brion William

Inhibition of plasma kallikrein by a highly specific active site blocking antibody

通过高度特异性的活性位点阻断抗体抑制血浆激肽释放酶

Jon A Kenniston, Ryan R Faucette, Diana Martik, Stephen R Comeau, Allison P Lindberg, Kris J Kopacz, Gregory P Conley, Jie Chen, Malini Viswanathan, Niksa Kastrapeli, Janja Cosic, Shauna Mason, Mike DiLeo, Jan Abendroth, Petr Kuzmic, Robert C Ladner, Thomas E Edwards, Christopher TenHoor, Burt A Ade

CYP2E1 substrate inhibition. MECHANISTIC INTERPRETATION THROUGH AN EFFECTOR SITE FOR MONOCYCLIC COMPOUNDS

CYP2E1底物抑制。通过单环化合物的效应位点进行机制解释

Frère, Jean-Marie A; Collom, Samuel L; Laddusaw, Ryan M; Burch, Amber M; Kuzmic, Petr; Perry, Martin D Jr; Miller, Grover P

Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases

用人类单克隆抗体特异性抑制组织激肽释放酶 1 揭示了其在呼吸道疾病中的潜在作用

Daniel J Sexton, Ting Chen, Diana Martik, Petr Kuzmic, Guannan Kuang, Jie Chen, Andrew E Nixon, Bruce L Zuraw, Rosanna M Forteza, William M Abraham, Clive R Wood

Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes

蛋白质-蛋白质相互作用的整体分析揭示了多个 CYP2E1-还原酶复合物

Arvind P Jamakhandi, Petr Kuzmic, Daniel E Sanders, Grover P Miller