日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

真核生物胆碱磷酸转移酶催化磷脂合成的结构基础和选择性

Roberts, Jacquelyn R; Horibata, Yasuhiro; Kwarcinski, Frank E; Lam, Vinson; Raczkowski, Ashleigh M; Hubbard, Akane; White, Betsy; Sugimoto, Hiroyuki; Tall, Gregory G; Ohi, Melanie D; Maeda, Shoji

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release

噻唑烷二酮类药物曲格列酮通过抑制GDP释放,直接与Gqα亚基结合,从而抑制Gq信号传导。

Issa, Naiem T; Shen, Tingzhen; Vizurraga, Alexander; Pronin, Alexey; Henry, Taylor; Wang, Qiang; Kwarcinski, Frank E; Schürer, Stephan; Badiavas, Evangelos; Tall, Gregory G; Slepak, Vladlen Z

GPR97/ADGRG3 is activated by its tethered peptide agonist and not by steroids to induce neutrophil polarization and migration

GPR97/ADGRG3受体由其连接的肽激动剂而非类固醇激活,从而诱导中性粒细胞极化和迁移。

Bernadyn, Tyler; Kwarcinski, Frank; Chandan, Naincy; Gandhi, Riya; Feng, Yuling; Holinstat, Michael; Parent, Carole A; Smrcka, Alan V; Tall, Gregory G

β-arrestin recruitment facilitates a direct association with G proteins.

β-arrestin 的募集促进其与 G 蛋白的直接结合。

Lee Claudia Y, Smith Jeffrey S, Kohlmann Taylor, Meara Emily M, Pham Uyen, Kwarcinski Frank, Dates Andrew N, Choi Issac, Hilibrand Ari S, Gillikin Abigail, Blacklow Stephen C, Tall Gregory G, Kruse Andrew C, Rajagopal Sudarshan

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore

发现具有 II 型抑制剂药效团的强效恶性疟原虫蛋白激酶 6 (PfPK6) 抑制剂

Han Wee Ong, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M Havener, Michael Chirgwin, Kareem A Galal, Caleb Willis, Andreas Krämer, Shubin Liu, Stefan Knapp, Emily R Derbyshire, Reena Zutshi, David H Drewry

Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms

Ric-8B 与 Gα 蛋白折叠客户端复合的结构揭示了异构体特异性机制

Makaía M Papasergi-Scott, Frank E Kwarcinski, Maiya Yu, Ouliana Panova, Ann M Ovrutsky, Georgios Skiniotis, Gregory G Tall

GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR

GPR114/ADGRG5 被其束缚肽激动剂激活,因为它是一种裂解粘附 GPCR

Tyler F Bernadyn, Alexander Vizurraga, Rashmi Adhikari, Frank Kwarcinski, Gregory G Tall

SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4

SGC-CLK-1:Cdc2 样激酶 CLK1、CLK2 和 CLK4 的化学探针

Deanna Tiek, Carrow I Wells, Martin Schröder, Xiao Song, Carla Alamillo-Ferrer, Anshika Goenka, Rebeca Iglesia, Minghui Lu, Bo Hu, Frank Kwarcinski, Parvathi Sintha, Chandi de Silva, Mohammad Anwar Hossain, Alfredo Picado, William Zuercher, Reena Zutshi, Stefan Knapp, Rebecca B Riggins, Shi-Yuan Che

The tethered peptide activation mechanism of adhesion GPCRs

粘附性GPCR的系链肽激活机制

Ximena Barros-Álvarez #,Robert M Nwokonko #,Alexander Vizurraga #,Donna Matzov #,Feng He,Makaía M Papasergi-Scott,Michael J Robertson,Ouliana Panova,Eliane Hadas Yardeni,Alpay B Seven,Frank E Kwarcinski,Hongyu Su,Maria Claudia Peroto,Justin G Meyerowitz,Moran Shalev-Benami,Gregory G Tall,Georgios Skiniotis

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

鉴定 4-苯胺基喹啉(唑)啉为细胞活性蛋白激酶新型 3 (PKN3) 抑制剂化学型

Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H