日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice

GIPR 激动剂增强肥胖 IR 小鼠中 TZD 诱导的胰岛素敏感性

Ellen C Furber, Karissa Hyatt, Kyla Collins, Xinxin Yu, Brian A Droz, Adrienne Holland, Jessica L Friedrich, Samantha Wojnicki, Debra L Konkol, Libbey S O'Farrell, Hana E Baker, Tamer Coskun, Philipp E Scherer, Christine M Kusminski, Michael E Christe, Kyle W Sloop, Ricardo J Samms

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

肠促胰岛素联合激动剂 tirzepatide 需要 GIPR 才能从人类胰岛分泌激素

Kimberley El #, Jonathan D Douros #, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B Wainscott, Bin Yang, Alex Chen, Donald Wothe, Callum Coupland, Mattias H Tschöp, Brian Finan, David A D'Alessio, Kyle W Sloop, Timo D Müller, Jonathan E Campbell5

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

胰岛 α 细胞的功能和增殖需要精氨酸转运蛋白 SLC7A2

Erick Spears, Jade E Stanley, Matthew Shou, Linlin Yin, Xuan Li, Chunhua Dai, Amber Bradley, Katelyn Sellick, Greg Poffenberger, Katie C Coate, Shristi Shrestha, Regina Jenkins, Kyle W Sloop, Keith T Wilson, Alan D Attie, Mark P Keller, Wenbiao Chen, Alvin C Powers, E Danielle Dean

14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing

14-3-3-zeta 介导 GLP-1 受体激动剂作用,从而改变 α 细胞胰高血糖素原加工

Marlena M Holter, Daryl J Phuong, Isaac Lee, Mridusmita Saikia, Lisa Weikert, Samantha Fountain, Elizabeth T Anderson, Qin Fu, Sheng Zhang, Kyle W Sloop, Bethany P Cummings

GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

GIPR 激动剂可抑制 PYY 诱发的恶心样行为

Ricardo J Samms, Richard Cosgrove, Brandy M Snider, Ellen C Furber, Brian A Droz, Daniel A Briere, James Dunbar, Mridula Dogra, Jorge Alsina-Fernandez, Tito Borner, Bart C De Jonghe, Matthew R Hayes, Tamer Coskun, Kyle W Sloop, Paul J Emmerson, Minrong Ai

GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells

GLP-1 受体信号增强人类 α 细胞中的 PCSK1 和 β 细胞特征

Mridusmita Saikia, Marlena M Holter, Leanne R Donahue, Isaac S Lee, Qiaonan C Zheng, Journey L Wise, Jenna E Todero, Daryl J Phuong, Darline Garibay, Reilly Coch, Kyle W Sloop, Adolfo Garcia-Ocana, Charles G Danko, Bethany P Cummings

Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

胰高血糖素阻断可恢复 1 型糖尿病小鼠的功能性 β 细胞质量并增强人类胰岛的功能

May-Yun Wang, E Danielle Dean, Ezekiel Quittner-Strom, Yi Zhu, Kamrul H Chowdhury, Zhuzhen Zhang, Shangang Zhao, Na Li, Reshing Ye, Young Lee, Yiyi Zhang, Shiuhwei Chen, Xinxin Yu, Derek C Leonard, Greg Poffenberger, Alison Von Deylen, S Kay McCorkle, Amnon Schlegel, Kyle W Sloop, Alexander M Efanov

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

替拉帕肽是一种不平衡且具有偏向性的双重GIP和GLP-1受体激动剂

Francis S Willard ,Jonathan D Douros ,Maria Bn Gabe ,Aaron D Showalter ,David B Wainscott ,Todd M Suter ,Megan E Capozzi ,Wijnand Jc van der Velden ,Cynthia Stutsman ,Guemalli R Cardona ,Shweta Urva ,Paul J Emmerson ,Jens J Holst ,David A D'Alessio ,Matthew P Coghlan ,Mette M Rosenkilde ,Jonathan E Campbell ,Kyle W Sloop

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

小鼠胰岛细胞GLP-1R基因与蛋白表达的不一致

Sarah M Gray, Yurong Xin, Elizabeth C Ross, Bryanna M Chazotte, Megan E Capozzi, Kimberley El, Berit Svendsen, Peter Ravn, Kyle W Sloop, Jenny Tong, Jesper Gromada, Jonathan E Campbell, David A D'Alessio

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

口服非肽激动剂 LY3502970 激活 GLP-1 受体的结构基础

Takahiro Kawai, Bingfa Sun, Hitoshi Yoshino, Dan Feng, Yoshiyuki Suzuki, Masanori Fukazawa, Shunsuke Nagao, David B Wainscott, Aaron D Showalter, Brian A Droz, Tong Sun Kobilka, Matthew P Coghlan, Francis S Willard, Yoshiki Kawabe, Brian K Kobilka, Kyle W Sloop