日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain

Ran 结合蛋白 2 对小分子热休克分子伴侣─晶体蛋白的蛋白质稳态重塑及其环丝氨酸结构域的肽基脯氨酰顺反异构酶和分子伴侣活性

Hemangi Patil, Haiqing Yi, Kyoung-In Cho, Paulo A Ferreira

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons

由 Ranbp2 缺失和视网膜神经节神经元核质运输障碍引起的肌萎缩侧索硬化症样模型中的小胶质细胞活化

Kyoung-In Cho, Dosuk Yoon, Minzhong Yu, Neal S Peachey, Paulo A Ferreira

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2

通过将 Ran GTPase 与 Ranbp2 的 Ran 结合域 3 分离,并鉴定出泛素结合酶 E2I (ubc9) 和 Ranbp2 的新型线粒体异构体,可导致年龄依赖性泛素蛋白稳态和选择性神经元结构完整性受损

Hemangi Patil, Dosuk Yoon, Reshma Bhowmick, Yunfei Cai, Kyoung-In Cho, Paulo A Ferreira

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes

运动神经元中 Ranbp2 的缺失会导致核质和趋化因子信号传导中断、hnRNPH3 和 Mmp28 的蛋白质稳态以及肌萎缩侧索硬化症样综合征的发展

Kyoung-In Cho, Dosuk Yoon, Sunny Qiu, Zachary Danziger, Warren M Grill, William C Wetsel, Paulo A Ferreira

Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin

利用新型小分子靶向 Ran 结合蛋白 2 (Ranbp2) 的环丝氨酸结构域来控制 STAT3、hnRNPA2B1 和 M-视蛋白的蛋白质稳态

Kyoung-In Cho, Andrew Orry, Se Eun Park, Paulo A Ferreira

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation

选择性损伤 Ran 结合蛋白 2 (Ranbp2) 的 Ran-GTP 结合域子集,足以重现由 Ranbp2 消融引发的视网膜色素上皮 (RPE) 退化

Hemangi Patil, Arjun Saha, Eugene Senda, Kyoung-in Cho, MdEmdadul Haque, Minzhong Yu, Sunny Qiu, Dosuk Yoon, Ying Hao, Neal S Peachey, Paulo A Ferreira

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis

Ran结合蛋白2(Ranbp2)的脯氨酰异构酶或分子伴侣活性的差异性丧失揭示了其环丝氨酸结构域在蛋白质稳态中的不同生理作用

Kyoung-in Cho, Hemangi Patil, Eugene Senda, Jessica Wang, Haiqing Yi, Sunny Qiu, Dosuk Yoon, Minzhong Yu, Andrew Orry, Neal S Peachey, Paulo A Ferreira

Increased tuberculosis burden due to demographic transition in Korea from 2001 to 2010

2001年至2010年韩国人口结构转型导致结核病负担加重

Park, Young Kil; Park, Yoon-Sung; Na, Kyoung In; Cho, En Hi; Shin, Sang-Sook; Kim, Hee Jin

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors

视锥细胞中 Ranbp2 特异性消融后,不同光感受器细胞类型之间会出现不同且非典型的内在和外在细胞死亡途径

Kyoung-In Cho, Mdemdadul Haque, Jessica Wang, Minzhong Yu, Ying Hao, Sunny Qiu, Indulekha C L Pillai, Neal S Peachey, Paulo A Ferreira

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress

RANBP2 不足引起的神经保护与氧化应激反应中功能多样但相互关联的通路对蛋白质和脂质稳态的调节有关

Kyoung-in Cho, Haiqing Yi, Nomingerel Tserentsoodol, Kelly Searle, Paulo A Ferreira