日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells

利用 DRx-098D 靶向破坏 TP53 野生型和突变型癌细胞中的 MDM2 同源二聚体和异源二聚体

Cooke, Sean F; Wright, Thomas A; Lappin, Gillian; Kyurkchieva, Elka; Sin, Yuan Yan; Ling, Jiayue; Zorn, Alina; O'Gorman, Bria; Banyard, William; Chang, Chih-Jung; Wheadon, Helen; Huang, Danny T; Baillie, George S; Blair, Connor M

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

利用新型蛋白水解靶向嵌合体对PDE4短型进行靶向蛋白降解

Sin Yuan Yan, Giblin Aoife, Judina Aleksandra, Rujirachaivej Punchita, Corral Laura G, Glennon Eliza, Tai Zhi Xian, Feng Tian, Torres Eduardo, Zorn Alina, Gorelik Julia, Kyurkchieva Elka, Yenchitsomanus Pa Thai, Swindlehurst Cathy, Chan Kyle, Stirling David, Baillie George S

Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders.

发现一种对PDE4B和PDE4D具有选择性的双功能降解剂,用于治疗慢性炎症性疾病。

Shakya Arvind, Liu Qiao, Lai Chon, Baker Sherry, Greene Steven, Erdman Paul, Rathnayake Athri, Schoolmeesters Angela, Blair Connor M, Kyurkchieva Elka, Rajapakse Navin, Lam Imelda, Sin Yuan Yan, Baillie George S, Huang Shenlin, Chourasia Aparajita H, Fung Leah