日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sensitivity of Tepotinib to Inhibitors or Inducers of CYP3A4 and P-Gp: Drug Interaction Studies and Physiologically-Based Pharmacokinetic Analysis

Tepotinib 对 CYP3A4 和 P-Gp 抑制剂或诱导剂的敏感性:药物相互作用研究和基于生理的药代动力学分析

Strotmann, Rainer; Lüpfert, Christian; Krebs-Brown, Axel; Ke, Alice; Boedding, Matthias; Heuer, Jürgen; Yeo, Karen Rowland; Benincosa, Lisa; Venkatakrishnan, Karthik

Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates

评估MET抑制剂tepotinib对CYP3A4和P-gp底物药代动力学的潜在影响

Yalkinoglu, Özkan; Becker, Andreas; Krebs-Brown, Axel; Vetter, Claudia; Lüpfert, Christian; Perrin, Dominique; Heuer, Jürgen; Biedert, Herlind; Hirt, Stefan; Bytyqi, Afrim; Bachmann, Angelika; Strotmann, Rainer

A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

一种评估细胞毒性前药依沃福酰胺的细胞色素P450介导的药物相互作用潜力的新型PBPK模型方法

Lüpfert, Christian; Dyroff, Martin; von Richter, Oliver; Gallemann, Dieter; El Bawab, Samer; Dolgos, Hugues; Jung, Don; Hecht, Stefan; Johne, Andreas

Population pharmacokinetic data analysis of three phase I studies of matuzumab, a humanised anti-EGFR monoclonal antibody in clinical cancer development

对马妥珠单抗(一种用于临床癌症研发的人源化抗EGFR单克隆抗体)的三项I期研究进行群体药代动力学数据分析

Kuester, K; Kovar, A; Lüpfert, C; Brockhaus, B; Kloft, C

Rate limitation of the Na(+),K(+)-ATPase pump cycle

Na(+),K(+)-ATPase泵循环的速率限制

Lüpfert, C; Grell, E; Pintschovius, V; Apell, H J; Cornelius, F; Clarke, R J

Influence of anions and cations on the dipole potential of phosphatidylcholine vesicles: a basis for the Hofmeister effect

阴离子和阳离子对磷脂酰胆碱囊泡偶极电位的影响:霍夫迈斯特效应的基础

Clarke, R J; Lüpfert, C

Hofmeister effects of anions on the kinetics of partial reactions of the Na+,K+-ATPase

阴离子对Na+,K+-ATP酶部分反应动力学的霍夫迈斯特效应

Ganea, C; Babes, A; Lüpfert, C; Grell, E; Fendler, K; Clarke, R J