日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy

化学遗传学方法激活海马CA2区可促进癫痫小鼠模型发生急性及慢性癫痫发作。

期刊:Neurobiology of Disease
影响因子:5.6
doi:10.1016/j.nbd.2025.107256
LaFrancois, John J; Kennedy, Meghan; Rathod, Monarchsinh; Santoro, Bina; Lisgaras, Christos Panagiotis; Siegelbaum, Steven A; Scharfman, Helen E
癫痫
神经科学
发表日期：2026
文献求助 收藏

Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats.

睾酮和 17β-雌二醇调节雄性和雌性大鼠海马区 CA3 尖波

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2025.115952
Pearce Patrice, LaFrancois John J, Skucas Vanessa, Friedman Daniel, Fenton André A, Dvorak Dino, MacLusky Neil J, Scharfman Helen E
Rat
发表日期：2025
文献求助 收藏

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer's disease

有证据表明，胆碱能机制在阿尔茨海默病早期阶段会导致过度兴奋。

期刊:Frontiers in Dementia
影响因子:
doi:10.3389/frdem.2025.1513144
Scharfman, Helen E; Kam, Korey; Duffy, Áine M; LaFrancois, John J; Leary, Paige; Chartampila, Elissavet; Ginsberg, Stephen D; Lisgaras, Christos Panagiotis
阿尔茨海默症
发表日期：2025
文献求助 收藏

Increasing adult-born neurons protects mice from epilepsy

增加成年期新生神经元的数量可以保护小鼠免受癫痫发作。

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.90893
Jain, Swati; LaFrancois, John J; Gerencer, Kasey; Botterill, Justin J; Kennedy, Meghan; Criscuolo, Chiara; Scharfman, Helen E
癫痫
神经科学
发表日期：2024
文献求助 收藏

Gastrointestinal nematode infection during pregnancy and lactation enhances spatial reference memory and reduces indicators of anxiety-like behaviour in uninfected adult female mouse offspring

妊娠和哺乳期胃肠道线虫感染可增强未感染成年雌性小鼠后代的空间参考记忆，并降低其焦虑样行为的指标。

期刊:Parasitology
影响因子:2.4
doi:10.1017/S0031182024000696
Noel, Sophia; LaFrancois, Ryan; Scott, Marilyn E
炎症/感染
发表日期：2024
文献求助 收藏

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy

颞叶癫痫小鼠模型中海马 CA2 区兴奋性增强及其对癫痫发作的贡献

期刊:Neuron
影响因子:14.7
doi:10.1016/j.neuron.2022.07.020
Alexander C Whitebirch, John J LaFrancois, Swati Jain, Paige Leary, Bina Santoro, Steven A Siegelbaum, Helen E Scharfman
神经
癫痫
Mouse
发表日期：2022
文献求助 收藏

Bidirectional Regulation of Cognitive and Anxiety-like Behaviors by Dentate Gyrus Mossy Cells in Male and Female Mice

雄性和雌性小鼠齿状回苔藓细胞对认知和焦虑样行为的双向调节

期刊:Journal of Neuroscience
影响因子:4.4
doi:10.1523/JNEUROSCI.1724-20.2021
Justin J Botterill, K Yaragudri Vinod, Kathleen J Gerencer, Cátia M Teixeira, John J LaFrancois, Helen E Scharfman
神经
焦虑症
其它细胞
发表日期：2021
文献求助 收藏

An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy

小鼠癫痫模型中齿状回苔藓细胞的兴奋和致痫作用

期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2019.10.100
Justin J Botterill, Yi-Ling Lu, John J LaFrancois, Hannah L Bernstein, David Alcantara-Gonzalez, Swati Jain, Paige Leary, Helen E Scharfman
神经
癫痫
其它细胞
Mouse
发表日期：2019
文献求助 收藏

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

损伤后 BACE1 表达的调节与 p75 神经营养因子受体有关

期刊:Molecular and Cellular Neuroscience
影响因子:2.6
doi:10.1016/j.mcn.2019.103395
Khalil Saadipour, Alexia Tiberi, Sylvia Lombardo, Elena Grajales, Laura Montroull, Noralyn B Mañucat-Tan, John LaFrancois, Michael Cammer, Paul M Mathews, Helen E Scharfman, Francesca-Fang Liao, Wilma J Friedman, Xin-Fu Zhou, Giueseppina Tesco, Moses V Chao
神经
发表日期：2019
文献求助 收藏

Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures

小鼠齿状回中的成年神经发生可保护海马免受严重癫痫发作后的神经元损伤

期刊:Hippocampus
影响因子:2.4
doi:10.1002/hipo.23062
Swati Jain, John J LaFrancois, Justin J Botterill, David Alcantara-Gonzalez, Helen E Scharfman
神经
癫痫
Mouse
发表日期：2019
文献求助 收藏