日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Compositional and functional differences of gut microbiome and metabolome inform pathogenesis of cholestatic liver disease

肠道微生物组和代谢组的组成和功能差异揭示了胆汁淤积性肝病的发病机制

期刊:Gut Microbes
影响因子:11
doi:10.1080/19490976.2026.2655793
Nikolaidis, Marios; Hu, Chang; Juran, Brian D; McCauley, Bryan M; Schlicht, Erik M; Bianchi, Jackie K; Ali, Ahmad H; Tragaki, Venetia; Atkinson, Elizabeth J; Johnson, Stephen; Mars, Ruben A; Eaton, John E; Carey, Elizabeth J; Franke, Andre; Schramm, Christoph; Kashyap, Purna C; Go, Young-Mi; Tran, ViLinh; Teeny, Sami; Jones, Dean P; Grant, Caroline W; Athreya, Arjun P; Miller, Gary W; LaRusso, Nicholas F; Gores, Gregory J; Karlsen, Tom H; Hov, Johannes R; Amoutzias, Grigorios D; Lazaridis, Konstantinos N
微生物学
代谢
发表日期：2026
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Central role for cholangiocyte pathobiology in cholestatic liver diseases

胆管细胞病理生物学在胆汁淤积性肝病中的核心作用

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000001093
Jalan-Sakrikar, Nidhi; Guicciardi, Maria Eugenia; O'Hara, Steven P; Azad, Adiba; LaRusso, Nicholas F; Gores, Gregory J; Huebert, Robert C
细胞生物学
发表日期：2025
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Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling

胆管细胞纤毛缺陷诱导持续的表皮生长因子受体信号传导

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000001055
Pant, Kishor; Richard, Seth; Peixoto, Estanislao; Baral, Subheksha; Yang, Rendong; Ren, Yanan; Masyuk, Tatyana V; LaRusso, Nicholas F; Gradilone, Sergio A
信号转导
细胞生物学
发表日期：2025
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Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress.

MYC 磷酸化差异驱动胆管细胞对压力的不同反应

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.4
doi:10.1016/j.jcmgh.2025.101547
O'Hara Steven P, Splinter Patrick L, Felzen Antonia, Turner Carys A, Morgenthaler Olivia T, Gores Gregory J, LaRusso Nicholas F
细胞生物学
磷酸化
发表日期：2025
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Targeting of a Bile Acid Receptor, Takeda G Protein Receptor 5 [TGR5], by a Novel First-in-Class Competitive Antagonist, SBI-364, Diminishes Hepatic and Renal Cystogenesis in Polycystic Liver and Kidney Disease

新型首创竞争性拮抗剂SBI-364靶向胆汁酸受体——武田G蛋白受体5 [TGR5]，可减少多囊肝肾疾病中的肝肾囊肿形成。

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00701
Masyuk, Tetyana; Masyuk, Anatoliy; Trussoni, Christy; Lorenzo-Pisarello, Maria; Ardecky, Robert; Pinkerton, Anthony; Sergienko, Edward; Olson, Steven; Zou, Jiwen; Ganji, Santhi Reddy; Kramer, Bryan; Vuong, Krystine; Jankowski, She-Chia; Ma, Chen-Ting; Holleran, John; Pollari, Sirkku; Brown, Brock; Ramachandra, Raghuveer; Chung, Thomas; Turner, Carys; Morgenthaler, Olivia; Kawashima, Hanako; LaRusso, Nicholas
信号转导
发表日期：2025
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Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression

在可逆性胆汁淤积小鼠模型中，胆管细胞的动态反应：巨噬细胞重塑和NF-Y介导的TGFβ1表达

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:3.3
doi:10.1152/ajpgi.00243.2025
Olson, Kirsta E; Krishnan, Anuradha; Splinter, Patrick; Wixom, Alexander Q; Guicciardi, Maria Eugenia; Jalan-Sakrikar, Nidhi; Azad, Adiba; LaRusso, Nicholas F; Gores, Gregory J
巨噬细胞
细胞生物学
巨噬细胞
TGFβ
免疫/内分泌
发表日期：2025
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Regulator of G-protein signaling expression in human intestinal enteroendocrine cells and potential role in satiety hormone secretion in health and obesity

人类肠道内分泌细胞中G蛋白信号表达的调节因子及其在健康和肥胖状态下饱腹激素分泌中的潜在作用

期刊:EBioMedicine
影响因子:9.7
doi:10.1016/j.ebiom.2024.105283
Alison N McRae ,Alexander L Ticho ,Yuanhang Liu ,Maria Laura Ricardo-Silgado ,Nothando N Mangena ,Fauzi Feris Jassir ,Daniel Gonzalez-Izundegui ,Gerardo Calderon ,Fariborz Rakhshan Rohakhtar ,Vernadette Simon ,Ying Li ,Cadman Leggett ,Daniela Hurtado ,Nicholas LaRusso ,Andres J Acosta
肥胖
细胞生物学
信号转导
免疫/内分泌
代谢
发表日期：2024
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Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis-methylomics of cholestatic liver disease

原发性硬化性胆管炎和原发性胆汁性胆管炎的表观遗传疾病标志物——胆汁淤积性肝病的甲基化组学

期刊:Hepatology Communications
影响因子:4.6
doi:10.1097/HC9.0000000000000496
Juran, Brian D; McCauley, Bryan M; Atkinson, Elizabeth J; Schlicht, Erik M; Bianchi, Jackie K; Vollenweider, Jason M; Ye, Hong; LaRusso, Nicholas F; Gores, Gregory J; Sun, Zhifu; Lazaridis, Konstantinos N
表观遗传
发表日期：2024
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The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1

表观遗传读取器，含溴结构域 2，通过与 ETS 原癌基因 1 相互作用介导胆管细胞衰老

期刊:Gastroenterology
影响因子:25.7
doi:10.1053/j.gastro.2023.03.235
Jeong-Han Kang, Patrick L Splinter, Christy E Trussoni, Nicholas E Pirius, Gregory J Gores, Nicholas F LaRusso, Steven P O'Hara
信号转导
肿瘤
其它细胞
Senescence
Human
发表日期：2023
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Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid

接受大剂量熊去氧胆酸治疗的原发性硬化性胆管炎患者的血清miRNA谱发生改变

期刊:Jhep Reports
影响因子:7.5
doi:10.1016/j.jhepr.2023.100729
Hochberg, Jessica T; Sohal, Aalam; Handa, Priya; Maliken, Bryan D; Kim, Take-Kyun; Wang, Kai; Gochanour, Eric; Li, Yu; Rose, J Bart; Nelson, James E; Lindor, Keith D; LaRusso, Nicholas F; Kowdley, Kris V
miRNA
发表日期：2023
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