Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity
嘌呤核苷磷酸化酶能够实现双重代谢检查点,从而预防T细胞免疫缺陷和TLR7相关的自身免疫性疾病。
期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI160852
Abt, Evan R; Rashid, Khalid; Le, Thuc M; Li, Suwen; Lee, Hailey R; Lok, Vincent; Li, Luyi; Creech, Amanda L; Labora, Amanda N; Mandl, Hanna K; Lam, Alex K; Cho, Arthur; Rezek, Valerie; Wu, Nanping; Abril-Rodriguez, Gabriel; Rosser, Ethan W; Mittelman, Steven D; Hugo, Willy; Mehrling, Thomas; Bantia, Shanta; Ribas, Antoni; Donahue, Timothy R; Crooks, Gay M; Wu, Ting-Ting; Radu, Caius G
T细胞
TLR7
信号转导
自身免疫性疾病
代谢
T细胞
磷酸化
细胞生物学
免疫/内分泌