Laboy Jocelyn T相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans

早老素基因突变破坏铁稳态，促进秀丽隐杆线虫中铁死亡介导的神经退行性变。

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2025.103910

Ryan, Kerry C; Laboy, Jocelyn T; Ashraf, Rabia; Ashkavand, Zahra; Jayasinghe, Isabel; Norman, Kenneth R

发表日期：2025

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Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal health

鉴定出具有足够γ-分泌酶蛋白水解活性以介导Notch信号通路但会破坏细胞器和神经元健康的早老素突变体。

期刊:Neurobiology of Disease

影响因子:5.6

doi:10.1016/j.nbd.2025.106961

Ashkavand, Zahra; Ryan, Kerry C; Laboy, Jocelyn T; Patel, Ritika; Geller, Brian; Norman, Kenneth R

细胞生物学

发表日期：2025

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C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity.

秀丽隐杆线虫早老素介导溶酶体活动所需的细胞器间接触和通讯

期刊:Aging and Disease

影响因子:6.9

doi:10.14336/AD.2024.0228

Ryan Kerry C, Ashkavand Zahra, Laboy Jocelyn T, Wang Ling, Barroso Margarida, Norman Kenneth R

细胞生物学

发表日期：2024

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DEC-7/SUSD2, a sushi domain-containing protein, regulates an ultradian behavior mediated by intestinal epithelial Ca(2+) oscillations in Caenorhabditis elegans

DEC-7/SUSD2 是一种含有寿司结构域的蛋白质，它调节秀丽隐杆线虫肠道上皮细胞 Ca(2+) 振荡介导的超昼夜节律行为。

期刊:American Journal of Physiology-Cell Physiology

影响因子:4.7

doi:10.1152/ajpcell.00552.2022

Laboy, Jocelyn T; Bonner, Jennifer; Norman, Kenneth R

细胞生物学

发表日期：2023

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Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

早老素缺失导致线粒体钙离子处理失调，破坏氧化还原稳态，促进神经元功能障碍

期刊:Antioxidants

影响因子:6.6

doi:10.3390/antiox11091642

Ryan, Kerry C; Laboy, Jocelyn T; Norman, Kenneth R

发表日期：2022

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Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

早老素缺失导致线粒体钙摄取增加和线粒体活性增强，进而促进 mTORC1 信号通路，驱动神经退行性变。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.13472

Ryan, Kerry C; Ashkavand, Zahra; Sarasija, Shaarika; Laboy, Jocelyn T; Samarakoon, Rohan; Norman, Kenneth R

发表日期：2021

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Corrupted ER-mitochondrial calcium homeostasis promotes the collapse of proteostasis

内质网-线粒体钙稳态紊乱会促进蛋白质稳态崩溃。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.13065

Ashkavand, Zahra; Sarasija, Shaarika; Ryan, Kerry C; Laboy, Jocelyn T; Norman, Kenneth R

蛋白质稳态

发表日期：2020

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Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

早老素基因突变会扰乱线虫线粒体Ca(2+)稳态和代谢活动，导致线虫神经退行性变。

影响因子:6.4

doi:10.7554/eLife.33052

Sarasija, Shaarika; Laboy, Jocelyn T; Ashkavand, Zahra; Bonner, Jennifer; Tang, Yi; Norman, Kenneth R

发表日期：2018

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