日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Kinetic Model of Antigen-Dependent IgG Oligomerization and Complement Binding

抗原依赖性IgG寡聚化和补体结合的动力学模型

Strasser, Jürgen; Frischauf, Nikolaus; Schustereder, Lukas; Karner, Andreas; Bosgra, Sieto; Labrijn, Aran F; Beurskens, Frank J; Preiner, Johannes

Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

IgG亚类激活补体的能力取决于它们在抗原结合后发生寡聚化的能力。

Frischauf, Nikolaus; Strasser, Jürgen; Borg, Ellen G F; Labrijn, Aran F; Beurskens, Frank J; Preiner, Johannes

Impact of structural modifications of IgG antibodies on effector functions

IgG抗体结构修饰对效应功能的影响

Damelang, Timon; Brinkhaus, Maximilian; van Osch, Thijs L J; Schuurman, Janine; Labrijn, Aran F; Rispens, Theo; Vidarsson, Gestur

The Influence of Human IgG Subclass and Allotype on Complement Activation.

人类 IgG 亚类和同种型对补体激活的影响

Damelang Timon, de Taeye Steven W, Rentenaar Rosa, Roya-Kouchaki Kasra, de Boer Esther, Derksen Ninotska I L, van Kessel Kok, Lissenberg-Thunnissen Suzanne, Rooijakkers Suzan H M, Jongerius Ilse, Mebius Mirjam M, Schuurman Janine, Labrijn Aran F, Vidarsson Gestur, Rispens Theo

Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity

TGN1412 抗 CD28 单克隆抗体下铰链突变可产生特异性 FcγRIIb 结合并保留超级激动剂活性

Alicia M Chenoweth, Sandra Esparon, Bruce D Wines, Janine Schuurman, Aran F Labrijn, P Mark Hogarth

Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

利用双特异性抗体靶向人类 CD73 上的两个不同表位可提高抗癌活性

Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren Wk Hansen, Morten F Gjerstorff, Christa E Müller, Paul Whi Parren, Henrik J Ditzel

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

DuoBody-CD3xCD20 在临床前模型中可诱导强效的 T 细胞介导的恶性 B 细胞杀伤作用,并为皮下给药提供了机会。

Engelberts, Patrick J; Hiemstra, Ida H; de Jong, Bart; Schuurhuis, Danita H; Meesters, Joyce; Beltran Hernandez, Irati; Oostindie, Simone C; Neijssen, Joost; van den Brink, Edward N; Horbach, G Jean; Verploegen, Sandra; Labrijn, Aran F; Salcedo, Theodora; Schuurman, Janine; Parren, Paul W H I; Breij, Esther C W

FcγR Binding and ADCC Activity of Human IgG Allotypes

人 IgG 同种异型的 FcγR 结合和 ADCC 活性

Steven W de Taeye, Arthur E H Bentlage, Mirjam M Mebius, Joyce I Meesters, Suzanne Lissenberg-Thunnissen, David Falck, Thomas Sénard, Nima Salehi, Manfred Wuhrer, Janine Schuurman, Aran F Labrijn, Theo Rispens, Gestur Vidarsson

CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory

CD3 双特异性抗体疗法将实体肿瘤转变为炎症部位,但不会安装保护性记忆

Hreinn Benonisson, Işıl Altıntaş, Marjolein Sluijter, Sandra Verploegen, Aran F Labrijn, Danita H Schuurhuis, Mischa A Houtkamp, J Sjef Verbeek, Janine Schuurman, Thorbald van Hall

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

控制 Fab 臂交换形成双特异性免疫球蛋白 G1 抗体的动力学机制

Dennis R Goulet, Steven J Orcutt, Adam Zwolak, Theo Rispens, Aran F Labrijn, Rob N de Jong, William M Atkins, Mark L Chiu