日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.

基因层面减少翻译抑制因子 FMRP 和 4E-BP2 可保护阿尔茨海默病小鼠模型的记忆力。

Ribeiro Felipe C, Cozachenco Danielle, Parkhill Michael, Rodrigue Brandon, Borges Caio, Lacaille Jean-Claude, Nader Karim, De Felice Fernanda G, Lourenco Mychael V, Aguilar-Valles Argel, Sonenberg Nahum, Ferreira Sergio T

Cell Type-Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory

细胞类型特异性 mTORC1 信号传导和翻译调控在突触可塑性和记忆中的作用

Huang, Ziying; Mahmood, Niaz; Wiebe, Shane; Khoutorsky, Arkady; Lacaille, Jean-Claude; Sonenberg, Nahum

Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation.

海马抑制性中间神经元特异性 DREADDs 治疗会改变 mTORC1-4E-BP 信号传导并损害记忆形成

Huang Ziying, Mahmood Niaz, Lacaille Jean-Claude, Wiebe Shane, Sonenberg Nahum

The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner

ISR下游靶标ATF4以细胞类型特异性方式抑制长期记忆。

Mahmood, Niaz; Choi, Jung-Hyun; Wu, Pei You; Dooling, Sean W; Watkins, Trent A; Huang, Ziying; Lipman, Jesse; Zhao, Hanjie; Yang, Anqi; Silversmith, Jake; Inglebert, Yanis; Koumenis, Constantinos; Sharma, Vijendra; Lacaille, Jean-Claude; Sossin, Wayne S; Khoutorsky, Arkady; McKinney, R Anne; Costa-Mattioli, Mauro; Sonenberg, Nahum

Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory.

GABA能中间神经元中mTORC1-4E-BP2信号传导失调会损害海马依赖性学习和记忆

Huang Ziying, Wiebe Shane, Nagpal Anmol, Choi Junghyun, Walters Caleb, Mahmood Niaz, Khoutorsky Arkady, Lacaille Jean-Claude, Sonenberg Nahum

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons

通过光遗传学和化学方法诱导海马生长抑素中间神经元兴奋性突触可塑性,从而刺激蛋白质合成

Honoré, Ève; Belo do Nascimento, Inês; Laplante, Isabel; Lacaille, Jean-Claude

Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses

小鼠的物体定位学习需要海马体生长抑素中间神经元的活动,并且由mTORC1介导的兴奋性突触长时程增强作用促进。

Honoré, Eve; Lacaille, Jean-Claude

Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission

IIIC型粘多糖贮积症的早期缺陷会破坏兴奋性突触传递。

Pará, Camila; Bose, Poulomee; Bruno, Luigi; Freemantle, Erika; Taherzadeh, Mahsa; Pan, Xuefang; Han, Chanshuai; McPherson, Peter S; Lacaille, Jean-Claude; Bonneil, Éric; Thibault, Pierre; O'Leary, Claire; Bigger, Brian; Morales, Carlos Ramon; Di Cristo, Graziella; Pshezhetsky, Alexey V

eIF2α controls memory consolidation via excitatory and somatostatin neurons

eIF2α通过兴奋性神经元和生长抑素神经元控制记忆巩固

Sharma, Vijendra; Sood, Rapita; Khlaifia, Abdessattar; Eslamizade, Mohammad Javad; Hung, Tzu-Yu; Lou, Danning; Asgarihafshejani, Azam; Lalzar, Maya; Kiniry, Stephen J; Stokes, Matthew P; Cohen, Noah; Nelson, Alissa J; Abell, Kathryn; Possemato, Anthony P; Gal-Ben-Ari, Shunit; Truong, Vinh T; Wang, Peng; Yiannakas, Adonis; Saffarzadeh, Fatemeh; Cuello, A Claudio; Nader, Karim; Kaufman, Randal J; Costa-Mattioli, Mauro; Baranov, Pavel V; Quintana, Albert; Sanz, Elisenda; Khoutorsky, Arkady; Lacaille, Jean-Claude; Rosenblum, Kobi; Sonenberg, Nahum

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

通过药物遗传学方法抑制eIF4E依赖的Mmp9 mRNA翻译可以逆转脆性X综合征样表型

Gkogkas, Christos G; Khoutorsky, Arkady; Cao, Ruifeng; Jafarnejad, Seyed Mehdi; Prager-Khoutorsky, Masha; Giannakas, Nikolaos; Kaminari, Archontia; Fragkouli, Apostolia; Nader, Karim; Price, Theodore J; Konicek, Bruce W; Graff, Jeremy R; Tzinia, Athina K; Lacaille, Jean-Claude; Sonenberg, Nahum