日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation

针对艰难梭菌 CDTb 的纳米抗体为强效毒素中和和高灵敏度定量提供了一套工具。

Nabukhotna, Kateryna; Kroh, Heather K; Anderson, David M; Cano Rodríguez, Rubén; Shupe, John A; McGresham, Maria; O'Neale, Carla V T; Shrem, Rebecca A; Wadzinski, Brian E; Schey, Kevin L; Spiller, Benjamin W; Lacy, D Borden

The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice

单克隆抗体AZD5148可对小鼠体内多种TcdB型艰难梭菌菌株提供广泛的保护作用。

Peritore-Galve, F Christopher; Kroh, Heather K; Shupe, John A; Ehni, Alyssa G; Cano Rodríguez, Rubén; Kordus, Shannon L; Washington, M Kay; Knippel, Reece J; Stanley, Ann Marie; Gamson, Adam; Tkaczyk, Christine; Lacy, D Borden

Mouse monoclonal antibodies against Clostridioides difficile toxins TcdA and TcdB target diverse epitopes for neutralization

针对艰难梭菌毒素TcdA和TcdB的小鼠单克隆抗体靶向不同的表位进行中和

Kroh, Heather K; Jensen, Jaime L; Wellnitz, Sabine; Park, Jeong Jin; Esadze, Alexandre; Huynh, Kevin W; Ammirati, Mark; Han, Seungil; Anderson, Annaliesa S; Lacy, D Borden; Gribenko, Alexey

Species-specific components of the Helicobacter pylori Cag type IV secretion system.

幽门螺杆菌 Cag IV 型分泌系统的物种特异性成分

Bryant Kaeli N, Frick-Cheng Arwen E, Solecki Lauren E, Kroh Heather K, McDonald W Hayes, Lacy D Borden, McClain Mark S, Ohi Melanie D, Cover Timothy L

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile

靶向细胞裂解机制促进艰难梭菌毒素的释放

Kordus, Shannon L; Nabukhotna, Kateryna; Rodríguez, Rubén Cano; Krystofiak, Evan; Childress, Kevin; Smith, Anna J; Loveridge, Natalie; Ball, William; Moore, Grace; Washington, M Kay; Markham, Nicholas; Lacy, D Borden

Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

艰难梭菌毒素:作用机制和抗毒素疗法

Kordus, Shannon L; Thomas, Audrey K; Lacy, D Borden

A low-cost, open-source evolutionary bioreactor and its educational use

一种低成本、开源的进化生物反应器及其教育用途

Gopalakrishnan, Vishhvaan; Crozier, Dena; Card, Kyle J; Chick, Lacy D; Krishnan, Nikhil P; McClure, Erin; Pelesko, Julia; Williamson, Drew F K; Nichol, Daniel; Mandal, Soumyajit; Bonomo, Robert A; Scott, Jacob G

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection

艰难梭菌毒素在感染过程中对葡萄糖基转移酶的依赖性和非依赖性作用

Peritore-Galve, F Christopher; Shupe, John A; Cave, Rory J; Childress, Kevin O; Washington, M Kay; Kuehne, Sarah A; Lacy, D Borden

Molecular architecture of bacterial type IV secretion systems

细菌IV型分泌系统的分子结构

Sheedlo, Michael J; Ohi, Melanie D; Lacy, D Borden; Cover, Timothy L

Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii

由缺乏致命毒素的索氏梭菌引起的持续性菌血症和腰大肌脓肿

Varley, Cara D; Rogers, Lisa M; Dixon, Beverly Rea; Bernard, Sarah C; Lacy, D Borden; Sulpizio, Emilio; Aronoff, David M; Townes, John M