日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain.

荧光 GLP1R/GIPR 双重激动剂探针揭示了胰腺和大脑中的细胞靶点

de Bray Anne, Roberts Anna G, Armour Sarah, Tong Jason, Huhn Christiane, Gatin-Fraudet Blaise, Roßmann Kilian, Shilleh Ali H, Jiang Wanqing, Figueredo Burgos Natalie S, Trott James P P, Viloria Katrina, Nasteska Daniela, Pearce Abigail, Miyazaki Satsuki, Tomlinson Jeremy W, Owen Dylan M, Nieves Daniel J, Ast Julia, Cyranka Malgorzata, Epanchintsev Alexey, Ämmälä Carina, Reimann Frank, Soykan Tolga, Ladds Graham, Adriaenssens Alice E, Trapp Stefan, Jones Ben, Broichhagen Johannes, Hodson David J

Reversing the triad of anaesthesia in a cannot intubate, cannot oxygenate emergency. Comment on Br J Anaesth 2024; 133: 190-2

在无法插管、无法供氧的紧急情况下逆转麻醉三联征。评论 Br J Anaesth 2024; 133: 190-2

Garland, Huw; Ladds, Graham

Loss-of-function Gα(s) rare disease variants exert mutation-specific effects on GPCR signaling

功能丧失的Gα(s)罕见疾病变异体对GPCR信号传导产生突变特异性影响

Redfern-Nichols, Theo; O'Brien, Shannon L; Huang, Xianglin; Medel-Lacruz, Brian; Calebiro, Davide; Selent, Jana; Ladds, Graham; Marti-Solano, Maria

GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of substance P release

GPR35激动剂通过抑制P物质释放来抑制TRPA1介导的结肠伤害感受。

Gupta, Rohit A; Higham, James P; Pearce, Abigail; Urriola-Muñoz, Paulina; Barker, Katie H; Paine, Luke; Ghooraroo, Joshua; Raine, Tim; Hockley, James R F; Rahman, Taufiq; St John Smith, Ewan; Brown, Alastair J H; Ladds, Graham; Suzuki, Rie; Bulmer, David C

Agonist efficacy at the β(2)AR is driven by the faster association rate of the G(s) protein.

β(2)AR 激动剂的效力取决于 G(s) 蛋白结合速率的加快

Harwood Clare R, Sykes David A, Redfern-Nichols Theo, Underwood Owen, Nicholson Colin, Khoshgrudi Armin N, Koers Eline J, Ladds Graham, Briddon Stephen J, Veprintsev Dmitry B

Receptor activity-modifying protein 3 enhances GLP-1-mediated insulin secretion

受体活性调节蛋白3增强GLP-1介导的胰岛素分泌

Pearce, Abigail; Kumari, Poonam; Sisk, Claudia M; Harris, Matthew; Yeung, Ho Yan; Winfield, Sabrina; Caron, Kathleen M; Ladds, Graham

Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology

用于研究G蛋白偶联受体信号传导和药理学的定量方法

Pearce, Abigail; Redfern-Nichols, Theo; Wills, Edward; Rosa, Matthew; Manulak, Iga; Sisk, Claudia; Huang, Xianglin; Atakpa-Adaji, Peace; Prole, David L; Ladds, Graham

Receptor Activity-Modifying Protein 3 enhances GLP-1-mediated Insulin Secretion

受体活性调节蛋白3增强GLP-1介导的胰岛素分泌

Pearce, Abigail; Kumari, Poonam; Sisk, Claudia M; Harris, Matthew; Yeung, Ho Yan; Winfield, Sabrina; Caron, Kathleen M; Ladds, Graham

Exploring bias in platelet P2Y(1) signalling: Host defence versus haemostasis

探索血小板 P2Y(1) 信号传导中的偏向性:宿主防御与止血

Pan, Dingxin; Ladds, Graham; Rahman, Khondaker Miraz; Pitchford, Simon C

Mechanistic Insights into the Adenosine A1 Receptor's Positive Allosteric Modulation for Non-Opioid Analgesics

腺苷A1受体对非阿片类镇痛药正向变构调节的机制研究

Weizmann, Tal; Pearce, Abigail; Griffin, Peter; Schild, Achille; Flaßhoff, Maren; Grossenbacher, Philipp; Lochner, Martin; Reynolds, Christopher A; Ladds, Graham; Deganutti, Giuseppe