日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation

人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。

Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly

Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action

疟原虫 SEY1 是一种新型可用药靶点,有助于咪唑并哌嗪的作用机制

Elizabeth Winzeler, Krypton Carolino, Mariana Laureano De Souza, Daisy Chen, Jean-Claude Farre, James Blauwkamp, Sabrina Absalon, Sonja Ghidelli-Disse, Alexander Morano, Jeffrey Dvorin, Maria Jose Lafuente-Monasterio, Francisco-Javier Gamo

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

多样化的进化途径挑战了使用附带敏感性作为抑制抵抗力的策略

Rebecca E K Mandt, Madeline R Luth, Mark A Tye, Ralph Mazitschek, Sabine Ottilie, Elizabeth A Winzeler, Maria Jose Lafuente-Monasterio, Francisco Javier Gamo, Dyann F Wirth, Amanda K Lukens

Development of an ectopic huLiver model for Plasmodium liver stage infection

疟原虫肝期感染异位肝移植模型的建立

Gabriela Samayoa-Reyes, Siobhan M Flaherty, Kristina S Wickham, Sara Viera-Morilla, Pamela M Strauch, Alison Roth, Laura Padrón, Conner M Jackson, Patricia Meireles, David Calvo, Wanlapa Roobsoong, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Gregory Reichard, Maria José Lafuente-Monasterio, Rosemar

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

抗癌人类 mTOR 抑制剂 sapanisertib 可有效抑制多种疟原虫激酶和生命周期阶段

Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Re

Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice

在人源化小鼠中开发具有抗疟活性的高选择性恶性疟原虫蛋白酶体抑制剂

Zhan, Wenhu; Zhang, Hao; Ginn, John; Leung, Annie; Liu, Yi J; Michino, Mayako; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Lafuente-Monasterio, Maria Jose; Martinez-Martinez, Maria Santos; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

吡咯基二氢乳清酸脱氢酶抑制剂系列先导化合物的优化及其在疟疾治疗中的应用

Kokkonda Sreekanth, Deng Xiaoyi, White Karen L, El Mazouni Farah, White John, Shackleford David M, Katneni Kasiram, Chiu Francis C K, Barker Helena, McLaren Jenna, Crighton Elly, Chen Gong, Angulo-Barturen Inigo, Jimenez-Diaz Maria Belen, Ferrer Santiago, Huertas-Valentin Leticia, Martinez-Martinez Maria Santos, Lafuente-Monasterio Maria Jose, Chittimalla Rajesh, Shahi Shatrughan P, Wittlin Sergio, Waterson David, Burrows Jeremy N, Matthews Dave, Tomchick Diana, Rathod Pradipsinh K, Palmer Michael J, Charman Susan A, Phillips Margaret A

Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases

通过 Jumonji 脱甲基酶抑制剂的转录重编程破坏恶性疟原虫的生命周期

Krista A Matthews, Kossi M Senagbe, Christopher Nötzel, Christopher A Gonzales, Xinran Tong, Filipa Rijo-Ferreira, Natarajan V Bhanu, Celia Miguel-Blanco, Maria Jose Lafuente-Monasterio, Benjamin A Garcia, Björn F C Kafsack, Elisabeth D Martinez

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

体外选择预测小鼠感染模型中疟原虫对二氢乳清酸脱氢酶抑制剂的耐药性

Rebecca E K Mandt, Maria Jose Lafuente-Monasterio, Tomoyo Sakata-Kato, Madeline R Luth, Delfina Segura, Alba Pablos-Tanarro, Sara Viera, Noemi Magan, Sabine Ottilie, Elizabeth A Winzeler, Amanda K Lukens, Francisco Javier Gamo, Dyann F Wirth

Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages

推动疟疾传播阻断药物的开放式创新:数百种分子靶向疟原虫早期蚊虫阶段

Delves, Michael; Lafuente-Monasterio, M Jose; Upton, Leanna; Ruecker, Andrea; Leroy, Didier; Gamo, Francisco-Javier; Sinden, Robert