日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology

罕见基因变异会增加患注意力缺陷多动障碍(ADHD)的风险,并与神经元生物学有关。

Demontis, Ditte; Duan, Jinjie; Hsu, Yu-Han H; Pintacuda, Greta; Grove, Jakob; Nielsen, Trine Tollerup; Thirstrup, Janne; Martorana, Makayla; Botts, Travis; Satterstrom, F Kyle; Bybjerg-Grauholm, Jonas; Tsai, Jason H Y; Glerup, Simon; Hoogman, Martine; Buitelaar, Jan; Klein, Marieke; Ziegler, Georg C; Jacob, Christian; Grimm, Oliver; Bayas, Maximilian; Kobayashi, Nene F; Kittel-Schneider, Sarah; Lesch, Klaus-Peter; Franke, Barbara; Reif, Andreas; Agerbo, Esben; Werge, Thomas; Nordentoft, Merete; Mors, Ole; Mortensen, Preben Bo; Lage, Kasper; Daly, Mark J; Neale, Benjamin M; Børglum, Anders D

Developmental convergence and divergence in human stem cell models of autism.

自闭症人类干细胞模型的发育趋同与分化。

Gordon Aaron, Yoon Se-Jin, Bicks Lucy K, Martín Jacqueline M, Pintacuda Greta, Arteaga Stephanie, Wamsley Brie, Guo Qiuyu, Elahi Lubayna, Dolmetsch Ricardo E, Bernstein Jonathan A, O'Hara Ruth, Hallmayer Joachim F, Lage Kasper, Pasca Sergiu P, Geschwind Daniel H

Deep learning-based stratification of Schizophrenia Spectrum Disorder from real-world data reveals distinct profiles of common and rare variant genetic signal

基于深度学习的真实世界数据对精神分裂症谱系障碍进行分层,揭示了常见和罕见变异基因信号的不同特征。

Cobuccio, Leonardo; Avellí, Marc Pielies; Webel, Henry; Medina, Ricardo Hernandez; Vaez, Morteza; Hellberg, Kajsa-Lotta Georgii; Hsu, Yu-Han H; Pintacuda, Greta; Rosengren, Anders; Werge, Thomas; Lage, Kasper; Rasmussen, Simon

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia

一个基础性的神经元蛋白网络模型,统一了精神分裂症中多模态的遗传、转录和蛋白质组扰动

Pintacuda, Greta; Hsu, Yu-Han H; Páleníková, Petra; Dubonyte, Ugne; Fornelos, Nadine; Chen, Miao; Mena, Daya; Biagini, Julia C; Botts, Travis; Martorana, Makayla; Rebelo, Danzel; Ching, Joshua K T; Crouse, Ethan; Gebre, Hilena; Adiconis, Xian; Haywood, Nathan; Simmons, Sean; Weïwer, Michel; Hawes, Derek; Pietilainen, Olli; Werge, Thomas; Li, Ka Wan; Smit, August B; Kirkeby, Agnete; Levin, Joshua Z; Nehme, Ralda; Lage, Kasper

Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation.

通过计算机模拟结合位点消融揭示了全基因组转录因子协同作用的规律

He Xuening, Einarsson Hjörleifur, Páleníková Petra, Rennie Sarah, Hu Dewei, Cui Ruining, Vaagensø Christian, Lage Kasper, Krautz Robert, Andersson Robin

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

通过对人胰腺癌进行单细胞RNA测序揭示成纤维细胞的动态演变

Dimitrieva, Slavica; Harrison, Jon M; Chang, Jonathan; Piquet, Michelle; Mino-Kenudson, Mari; Gabriel, Millicent; Sagar, Vivek; Horn, Heiko; Lage, Kasper; Kim, Julie; Li, Gang; Weng, Shaobu; Harris, Cynthia; Kulkarni, Anupriya S; Ting, David T; Qadan, Motaz; Fagenholz, Peter J; Ferrone, Cristina R; Grauel, Angelo L; Laszewski, Tyler; Raza, Alina; Riester, Markus; Somerville, Tim; Wagner, Joel P; Dranoff, Glenn; Engelman, Jeffrey A; Kauffmann, Audrey; Leary, Rebecca; Warshaw, Andrew L; Lillemoe, Keith D; Fernández-Del Castillo, Carlos; Ruddy, David A; Liss, Andrew S; Cremasco, Viviana

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

利用基因特征的多基因富集来预测复杂性状和疾病的潜在基因

Weeks, Elle M; Ulirsch, Jacob C; Cheng, Nathan Y; Trippe, Brian L; Fine, Rebecca S; Miao, Jenkai; Patwardhan, Tejal A; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P; Tashman, Katherine C; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S; Biton, Moshe; Shalek, Alex K; Ananthakrishnan, Ashwin N; Xavier, Ramnik J; Regev, Aviv; Gupta, Rajat M; Lage, Kasper; Ardlie, Kristin G; Hirschhorn, Joel N; Lander, Eric S; Engreitz, Jesse M; Finucane, Hilary K

Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells

利用患者来源的诱导多能干细胞构建精神分裂症模型的最新进展

Dubonyte, Ugne; Asenjo-Martinez, Andrea; Werge, Thomas; Lage, Kasper; Kirkeby, Agnete

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility

共表达网络结构揭示了疾病易感性的全脑和多区域基础

Hartl, Christopher L; Ramaswami, Gokul; Pembroke, William G; Muller, Sandrine; Pintacuda, Greta; Saha, Ashis; Parsana, Princy; Battle, Alexis; Lage, Kasper; Geschwind, Daniel H

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

通过估计风险预测的置信区间,将多基因风险评分转化为临床应用。

Sun, Jiangming; Wang, Yunpeng; Folkersen, Lasse; Borné, Yan; Amlien, Inge; Buil, Alfonso; Orho-Melander, Marju; Børglum, Anders D; Hougaard, David M; Melander, Olle; Engström, Gunnar; Werge, Thomas; Lage, Kasper