SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
SIRT4具有肿瘤抑制活性，并通过抑制线粒体谷氨酰胺代谢来调节细胞对DNA损伤的代谢反应。
期刊:Cancer Cell
影响因子:44.5
doi:10.1016/j.ccr.2013.02.024
Jeong, Seung Min; Xiao, Cuiying; Finley, Lydia W S; Lahusen, Tyler; Souza, Amanda L; Pierce, Kerry; Li, Ying-Hua; Wang, Xiaoxu; Laurent, Gaëlle; German, Natalie J; Xu, Xiaoling; Li, Cuiling; Wang, Rui-Hong; Lee, Jaewon; Csibi, Alfredo; Cerione, Richard; Blenis, John; Clish, Clary B; Kimmelman, Alec; Deng, Chu-Xia; Haigis, Marcia C
肿瘤
肿瘤免疫
代谢
线粒体
细胞生物学
毒理研究
SIRT4
