Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle
己烯雌酚(DES)刺激的激素毒性是通过雌激素受体α(ERα)改变小鼠精囊中靶基因的甲基化模式和表观遗传修饰因子(DNMT3A、MBD2和HDAC2)介导的。
期刊:Environmental Health Perspectives
影响因子:9.8
doi:10.1289/ehp.1307351
Li, Yin; Hamilton, Katherine J; Lai, Anne Y; Burns, Katherine A; Li, Leping; Wade, Paul A; Korach, Kenneth S
表观遗传
信号转导
HDAC2
MBD2
DNMT3A
毒理研究
免疫/内分泌