日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain.

mdx营养不良脑中分子和功能异常的时空多样性

Pomeroy Joanna, Borczyk Malgorzata, Kawalec Maria, Hajto Jacek, Carlson Emma, Svärd Samuel, Verma Suraj, Bareke Eric, Boratyńska-Jasińska Anna, Dymkowska Dorota, Mellado-Ibáñez Alvaro, Laight David, Zabłocki Krzysztof, Occhipinti Annalisa, Majewska Loydie, Angione Claudio, Majewski Jacek, Yegutkin Gennady G, Korostynski Michal, Zabłocka Barbara, Górecki Dariusz C

Quantification and structure-function analysis of calpain-1 and calpain-2 protease subunit interactions

钙蛋白酶-1和钙蛋白酶-2亚基相互作用的定量和结构-功能分析

Ivan Shapovalov ,Prawin Rimal ,Pitambar Poudel ,Victoria Lewtas ,Mathias Bell ,Shailesh Kumar Panday ,Brian J Laight ,Danielle Harper ,Stacy Grieve ,George S Baillie ,Kazem Nouri ,Peter L Davies ,Emil Alexov ,Peter A Greer

Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses

bintrafusp alfa 通过促进 T 效应细胞和 NK 细胞反应,阻断 TGF-β 和 PD-L1,从而提高临床前卵巢癌模型的生存率。

Jacob Kment # ,Daniel Newsted # ,Stephanie Young ,Michael C Vermeulen ,Brian J Laight ,Peter A Greer ,Yan Lan ,Andrew W Craig

Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

癌细胞基因型相关的肿瘤免疫微环境在高级别浆液性卵巢癌中对治疗性 STING 通路激活表现出不同的反应

Noor Shakfa, Deyang Li, Gwenaelle Conseil, Elizabeth D Lightbody, Juliette Wilson-Sanchez, Ali Hamade, Stephen Chenard, Natasha A Jawa, Brian J Laight, Afrakoma Afriyie-Asante, Kathrin Tyryshkin, Martin Koebel, Madhuri Koti

Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes

阐明FES酪氨酸激酶在脓毒症的发病机制、病理生理学、严重程度及其预后中的作用

Laight, Brian J; Jawa, Natasha A; Tyryshkin, Kathrin; Maslove, David M; Boyd, J Gordon; Greer, Peter A

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

病毒编程的细胞外囊泡使癌细胞对溶瘤病毒和小分子疗法敏感

Marie-Eve Wedge #, Victoria A Jennings #, Mathieu J F Crupi #, Joanna Poutou #, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza R

Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy-induced Metastasis

靶向 Ezrin 衔接蛋白可增强转移性乳腺癌细胞对化疗的敏感性,并减少新辅助治疗引起的转移

Victoria Hoskin, Abdi Ghaffari, Brian J Laight, Sandip SenGupta, Yolanda Madarnas, Christopher J B Nicol, Bruce E Elliott, Sonal Varma, Peter A Greer

Personalized oncology and BRAF(K601N) melanoma: model development, drug discovery, and clinical correlation.

个性化肿瘤学和 BRAF(K601N) 黑色素瘤:模型开发、药物发现和临床相关性

Keller Brian A, Laight Brian J, Varette Oliver, Broom Aron, Wedge Marie-Ève, McSweeney Benjamin, Cemeus Catia, Petryk Julia, Lo Bryan, Burns Bruce, Nessim Carolyn, Ong Michael, Chica Roberto A, Atkins Harold L, Diallo Jean-Simon, Ilkow Carolina S, Bell John C

A randomised placebo controlled trial of VSL#3® probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease

VSL#3® 益生菌对非酒精性脂肪肝疾病的心血管风险和肝损伤生物标志物的随机安慰剂对照试验

Pui Lin Chong, David Laight, Richard J Aspinall, Antony Higginson, Michael H Cummings

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.

人肺微血管内皮细胞中的囊性纤维化跨膜传导调节因子(CFTR)控制氧化应激、活性氧介导的细胞信号传导和炎症反应

Khalaf Maha, Scott-Ward Toby, Causer Adam, Saynor Zoe, Shepherd Anthony, Górecki Dariusz, Lewis Anthony, Laight David, Shute Janis